Amir Suleman, Munawar Zaman, Muhammad Yasin, Abdur -Rab Khan


Background: Priority of all bronchoscopies has been diagnostic yield and various techniques have been introduced to improve it. Transbronchial biopsy (TBB) and transbronchial aspirates (TBA) also play an important role in improving diagnostic yield. The aim of the study was to determine the diagnostic yield of biopsies via fibre optic bronchoscopy (FOB) in 108 cases in which it was indicated. Methods: This was a cross-sectional study conducted in the Pulmonology department of Ayub teaching Hospital Abbottabad. Patients of all ages, sex and occupation on whom bronchoscopies were performed were included in the study. Bronchial biopsies were taken. Results: Out of 108 patients, who were biopsied, malignancy was confirmed in 48%, benign lesions in 49% and only 3% were non-diagnostic biopsies. Conclusion: Diagnostic yield of FOB is good and is very useful for the diagnosis of pulmonary lesions.

Keywords: Fiberoptic, Bronchoscopy, Diagnostic yield, Endobronchial biopsy, Transbronchial biopsy, segmental bronchi.

Full Text:



Joos L, Patuto N, Chhajed PN, Tamm M. Diagnostic yield of flexible bronchoscopy in current clinical practice. Swiss Med Wkly 2006;136(9-10):155–9.

Herth FJ, Schuler H, Gompelmann D, Kahn N, Gasparini S, Ernst A. Endobronchial ultrasound- guided lymph node biopsy with transbronchial needle forceps, a pilot study. Eur Respir J 2011;39(2):373–7.

Becker HD, Killian G: A Biographical Sketch. J Bronchal 1995; 2:77–83.

Ikeda S, Yanai N, Ioshikawa S. Flexible bronchofibroscope. Keio J Med 1968;17:1–16.

Greig JH, Cooper SM, Kasimbazi HJ, Monie RD, Fennerty AG, Watson B. Sedation for fiber optic bronchoscopy Respir Med 1995;89:53–6.

Buccheri G, Barberis P, Delfino MS: Diagnostic, morphologic and histopathologic correlates in bronchogenic carcinoma. A review of 1045 bronchoscopic examinations. Chest 1991;99:809–14.

Rivera MP, Mehta AC; American College of Chest Physicians. Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007;132(3 supply):131S–48S.

Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160(2):736–55.

Green MB, Allen JN. Cough, dyspnea and reticonodular opacities in a 58-year-old smoker. Chest 2007;132(2):700–3.

Moner JM, Saldana MJ, Oldham SA. Diagnosis of pneumocystis carini pneumonia. Roetgenographic pathologic correlates. Based on fiber optic bronchoscopy specimen from patient with acquired immunodeficiency syndrome. Chest 1986;89:522–6.

Venkateshiah SB, Mehta AC. Role of flexible bronchoscopy in the diagnosis of pulmonary tuberculosis in immunocompetent individuals. J Bronchal 2003;10:300–8.

Szlubowski A, Soja J, Kuzdzał J, Zieliński M, Sładek K. Transbronchial lung biopsy as diagnostic method of peripheral lesions. Pneumonol Alergol Pol 2004;72:482–6.

Hernández Blasco L, Sánchez Hernández IM, Villena Garrido V, de Miguel Poch E, Nuñez Delgado M, Alfaro Abreu J. Safety of transbronchial biopsy in outpatients. Chest 1991;99:562–5.

Wahidi MM, Rocha AT, Hollingsworth JW, Govert JA, Feller-Kopman D, Ernst A. Contraindications and safety of the transbronchial lung biopsy via flexible bronchoscopy. A survey of pulmonologists and review of the literature. Respiration 2005;72;285–95.

Ernst A, Eberhardt R, Wahidi M, Becker HD, Herth FJ. Effect of routine clopidogril use on bleeding complications after transbronchial biopsy in humans. Chest 2006;129:734–7.

Tanaka H, Yamada G, Saikai T, Hashimoto M, Tanaka S, Suzuki K, et al. Increased airway vascularity in newly diagnosed asthma using a high magnification bronchovideoscope. Am J Respircrit care Med 2003;168:1495–9.

Schuurmans MM, Michaud GC, Diacon AH, Bolliger CT. Use of an ultrathin bronchoscope in the assessment of central airway obstruction. Chest 2003;124;735–9.

Sawy MS, Jayakrishnan B, Behbehani N, Abal AT, El-Shamy A, Nair MG. Flexible fibreoptic bronchoscopy. Diagnostic yield. Saudi Med J 2004;25(10);1459–63.

Prasad R, James P, Keservani V, Gupta R, Pant MC, Chaturvedi A, et al. Clinicopathological study of bronchogenic carcinoma. Respirology 2004,9(4):557–60.

Kramer H, Groen HJ. Current concepts in the mediastinal lymph node staging of non small cell lung cancer. Ann Surg 2003;238:180–8.

Inoue Y, Trapnell BC, Tazwa R, Arai T, Takada T, Hizawa N et al. Characteristic of large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. Am J Respir Crit Care Med 2008;177:752–62


  • There are currently no refbacks.

Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]