RELATIONSHIP OF THYROID-STIMULATING HORMONE WITH METABOLIC SYNDROME IN A SAMPLE OF EUTHYROID PAKISTANI POPULATION

Muhammad Shahzad Saleem, Tanvir Ali Khan Shirwany, Khurshid Ahmad Khan

Abstract


Background: Metabolic Syndrome is a group of factors that predispose to cardiovascular diseases.
The prevalence of metabolic syndrome is rising rapidly. Recently, a few studies have suggested that
lower thyroid function in the reference range may be associated with metabolic syndrome, but the
issue remains unsettled. We aimed to elucidate the relationship between thyroid function and
components of metabolic syndrome in a sample of euthyroid Pakistani population. Methods: This
analytical, cross-sectional study was conducted at the Department of Physiology, University of
Health Sciences, Lahore, Pakistan, and extended over a period of 12 months. It included 100 subjects
with metabolic syndrome in the study group and thirty subjects without metabolic syndrome in the
control group with age ranging 45–55 years. Both groups had normal thyroid function. After a
detailed history and clinical examination, fasting blood was analysed for glucose, triglycerides, high
density lipoprotein-cholesterol along with thyroid-stimulating hormone (TSH) and free thyroxine.
Results: Serum TSH was significantly higher in study group than in control group (p=0.040). Serum
free thyroxine values of study group were slightly but not significantly lower than those of control
group. Serum TSH correlated significantly and positively with serum triglycerides in all subjects and
with waist circumference and diastolic blood pressure in men. Serum TSH showed a positive and
linear relationship with the number of components of metabolic syndrome (p=0.016) in all subjects.
Conclusion: High-normal TSH is associated with metabolic syndrome and its components. There
may be increased risk of cardiovascular diseases with high-normal TSH levels.
Keywords: Thyroid Stimulating Hormone, Metabolic Syndrome, Euthyroid

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