COMPARISON OF DIFFERENT FORMULATIONS OF VITAMIN D
Abstract
Background: Vitamin D Deficiency (VDD) is responsible for a wide spectrum of clinical diseases and vitamin D deficiency prevalence is frightening in most parts of the world including Pakistan. Therefore, supplementations of vitamin D are used in the population at high risk for the prevention and the treatment of vitamin D deficiency. Vitamin D supplementation comes in various formulations both oral and intramuscular. Cholecalciferol is the most commonly used preparation which is given through these routes of administration. There is need to study the fact that how much vitamin D levels are raised after administration of these different formulations as this can be a pivotal factor in determining dosage and route of vitamin D3. Methods: This cross-sectional study conducted on 320 cases and compared the efficacy of various Vitamin D3 preparations in raising Vitamin D levels conducted in Department of Endocrinology and Metabolism, Services Hospital, Lahore from February to July, 2016. Blood serum was drawn for vitamin D level in the cases at the time of presentation and after treatment. Results: Three hundred & twenty patients were enrolled in study and divided into four groups (A, B, C, D). There was no significant difference between groups (A, B, C, D) in change in vitamin d levels after 3 months of treatment (p-Value 0.446). Conclusion: Different preparations of vitamin D are equally effective in raising vitamin D levels at 12 weeks. However, there is a need to conduct large scale studies to further validate these results.Keywords: Deficiency; Vitamin D; Administration; Dosage; EfficacyReferences
Hossein-nezhad A, Holick MF. Vitamin D for health: A global perspective. Mayo Clin Proc 2013;88(7):720–55.
Holick MF. Vitamin D deficiency. N Engl J Med 2007;357(3):266–8.
Ganji V, Zhang X, Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr 2012;142(3):498–507.
Greene-Finestone LS, Berger C, de Groh M, Hanley DA, Hidiroglou N, Sarafin K, et al. 25-Hydroxyvitamin D in Canadian adults: Biological, environmental, and behavioral correlates. Osteoporos Int 2011;22(5):1389–99.
Riaz H, Finlayson AE, Bashir S, Hussain S, Mahmood S, Malik F, et al. Prevalence of Vitamin D deficiency in Pakistan and implications for the future. Expert Rev Clin Pharmacol 2016;9(2):329–38.
Garg MK, Marwaha RK, Khadgawat R, Ramot R, Obroi AK, Mehan N, et al. Efficacy of Vitamin D loading doses on serum 25-hydroxy Vitamin D levels in school going adolescents: An open label non-randomized prospective trial. J Pediatr Endocrinol Metab 2013;26(5-6):515–23.
Agarwal KS, Mughal MZ, Upadhyay P, Berry JL, Mawer EB, Puliyel JM. The impact of atmospheric pollution on Vitamin D status of infants and toddlers in Delhi, India. Arch Dis Child 2002;87(2):111–3.
Gupta R, Gupta A. Vitamin D deficiency in India: Prevalence, causalities and interventions. Nutrients 2014;6(2):729–75.
Vieth R, Carter G. Difficulties with Vitamin D nutrition research: Objective targets of adequacy, and assays for 25-hydroxyvitamin D. Eur J Clin Nutr 2001;55(4):221–2.
Grossmann RE, Tangpricha V. Evaluation of vehicle substances on vitamin D bioavailability: A systematic review. Mol Nutr Food Res 2010;54(8):1055–61.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96(7):1911–30.
Dietary Reference Intakes for Calcium and Vitamin D. [Internet]. Washington, D.C.: National Academies Press; 2011 [cited 2012 Jun 17]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56070/
Pepper KJ, Judd SE, Nanes MS, Tangpricha V. Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Endocr Pract 2009;15(2):95–103.
Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev 2008;13(1):6–20.
Matthana MH. The relation between vitamin D deficiency and fibromyalgia syndrome in women. Saudi Med J 2011;32(9):925–9.
Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014;18(45):1–190.
Sahay M, Sahay R. Rickets–vitamin D deficiency and dependency. Indian J Endocrinol Metab 2012;16(2):164–76.
Confino-Cohen R, Brufman I, Goldberg A, Feldman BS. Vitamin D, asthma prevalence and asthma exacerbations: a large adult population-based study. Allergy 2014;69(12):1673–80.
Ben-Shoshan M. Vitamin D deficiency/insufficiency and challenges in developing global vitamin D fortification and supplementation policy in adults. Int J Vitam Nutr Res 2012;82(4):237–59.
Babu US, Calvo MS. Modern India and the Vitamin D dilemma: Evidence for the need of a national food fortification program. Mol Nutr Food Res 2010;54(8):1134–47.
Allen LH, De Benoist B, Dary O, Hurrell R, World Health Organization. Guidelines on food fortification with micronutrients. 2006.
Calvo MS, Whiting SJ. Public health strategies to overcome barriers to optimal Vitamin D status in populations with special needs. J Nutr 2006;136(4):1135–9.
National Institute of Nutrition, Indian Council of Medical Research, Nutrient Requirements and Recommended Dietary Allowances for Indians. A Report of the Expert Group of the Indian Council of Medical Research. Hyderabad: 2009.
Mustafa MA, Jali IM. Oral or Intramuscular Vitamin D Replacement? Glo Adv Res J Med Med Sci 2015;4(6):277–80.
Cipriani C1, Romagnoli E, Pepe J, Russo S, Carlucci L, Piemonte S, et al. Long-term bioavailability after a single oral or intramuscular administration of 600,000 IU of ergocalciferol or cholecalciferol: implications for treatment and prophylaxis. J Clin Endocrinol Metab 2013;98(7):2709–15.
Zabihiyeganeh M, Jahed A, Nojomi M. Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral vs intramuscular; an open labeled RCT. Clin Endocrinol (Oxf) 2013;78(2):210–6.
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