β-THALASSAEMIA TRAIT: HAEMATOLOGICAL PARAMETERS

Authors

  • Yasar M Yousafzai
  • Shahtaj Khan
  • Fazle Raziq

Abstract

Background: β-Thalassaemia syndromes are a group of hereditary disorders characterised by a geneticdeficiency in the synthesis of β-globin chains due to a defect in β-globin genes. The objective of thisstudy was to determine the haematological features of β-thalassaemia trait (BTT), and to determine thesensitivity of Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH) andMentzer Index (MI) as a screening tool for β-thalassaemia trait. Methods: A descriptive study wasconducted in Hayatabad Medical Complex, Peshawar from May 2009 to May 2010 with 203 subjectshaving BTT. Blood samples were collected in EDTA anti-coagulated tubes. RBC indices were taken aspart of complete blood count (CBC) by haematology analyser, and Haemoglobin (Hb) electrophoresiswas done to determine the HbA2 percentage. The data was collected and analyzed on statisticalsoftware for demographic details, RBC indices and HBA2 levels. Results: Out of 203 patients, 92(45%) were males and 111 (55%) were females. Most patients tested were in the 15–45 year age group.One-hundred-sixty (79%) patients had anaemia. MCV was lower than 76 fl in all the cases. MeanMCV was 59.1 fl. MCH was low, the mean MCH being 19.3 g/dl. MCH <26 gave sensitivity of 99%in detecting BTT. We calculated MI for these cases and found out that it was <12 in 75% of cases and<15 in 197 (97%). Conclusion: β-thalassaemia traits present with a microcytic hypochromic bloodpicture, detected on simple haematology analysers as low MCV and MCH and MI which provide auseful screening tool for β- thalassaemia trait.Keywords: β-Thalassaemia, Thalassaemia Minor, haemoglobinopathy

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Published

2010-12-01

Issue

Vol. 22 No. 4 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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