Mohammad Shoaib Khan, Zahoor Ahmed, Rohila Hanif, Safeer Zaman, Irshad Ali, Jamil Ur Rahman, Fasseh -uz- Zaman


Background: Blood is man’s complete and unchangeable identity. The ABO and Rh groups are
recognised as major and clinically significant blood groups. Blood group antigens are not only
important in relation to blood transfusion and organ transplantation, but also have been utilised in
genetic research, anthropology and tracing ancestral relation of humans. The objective the present
study is to examine the blood group antigens in infertile men for assessing the relationship to male
infertility and to know the frequency of various blood groups among infertile males in our
population. Method: A total of 1,521 patients along with 460 proven fathers as controls were
recruited for the present study from both rural and urban areas of Pakistan and referred to
Department of Reproductive Physiology/Health, Public Health Divisions, NIH, Islamabad, during
2002 to 2006. Blood grouping (ABO) and Rhesus factors (Rh) was done by the antigen antibody
agglutination test. Results: Overall distribution of blood groups in the studied population of 1,521
subjects was 35.50%, 28.27%, 26.89% and 9.34% for blood groups O, B, A and AB respectively.
The ratio of control to patient was 1:3.3. Conclusions: The present preliminary study revealed that in
our population the prevalence of male infertility in blood group O is invariably higher than in all
other ABO blood groups, showing a strong relationship between blood group O and male infertility.
Keywords: Blood groups, Male infertility, Pakistani population

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