MATERNAL SERUM LEVELS OF ADIPONECTIN IN PREECLAMPSIA
Abstract
Background: The results of the serum levels of adiponectin in preeclamptic patients areconflicting. Objective: The aim of the present study was to assess serum levels of adiponectin inwomen with preeclampsia compared with healthy pregnant women. Methods: A cross-sectionalstudy was designed. The case group consisted of women with preeclampsia (n=30). The controlgroup consisted of 30 matched normal pregnant women. Serum levels of adiponectin wereassessed using enzyme-linked immunosorbent assay method. Results: Serum levels of adiponectinwere significantly higher in the preeclamptic group than those in the normal control group. In thepreeclamptic patients serum levels of adiponectin showed a significant negative correlation withbody mass index while no correlation was found in the normal pregnant women. In women withpreeclampsia, levels of adiponectin were decreased significantly in the overweight womencompared with normal weight women, while in the control group no significant difference wasobserved. Conclusion: In conclusion, elevation of adiponectin levels might be a physiologicalfeedback response to minimize endothelial dysfunction in preeclamptic patients.Keywords: Serum, Adiponectin, Preeclampsia, Pregnancy, BMI, ELISA.References
Mumtaz F, Memon AR, Yousfani S, Tahir SM, Khushk I,
Memon M, et al. Role of serum leptin level as a marker of
severity of pre eclampsia. J Ayub Med Coll Abbottabad.
;20(1):13–5.
Iftikhar U, Khoja A, Iqbaal MA, Karrira KA. Evaluation of
serum leptin levels during normal pregnancy and in preeclampsia. J Ayub Med Coll Abbottabad 2008;20(4):137–40.
Nakatsukasa H, Masuyama H, Takamoto N, Hiramatsu Y.
Circulating leptin and angiogenic factors in preeclampsia
patients. Endocr J 2008;55:565–73.
Mohaupt M. Molecular aspects of preeclampsia. Mol Aspects
Med 2007;28:169–91
Mutter WP, Karumanchi SA. Molecular mechanisms of
preeclampsia. Microvas Res 2008;75:1–8
Lu D, Yang X, Wu Y, Wang H, Huang H, Dong M. Serum
adiponectin, leptin and soluble leptin receptor in preeclampsia. Int J Gynaecol Obstet 2006;95:121–6.
Takemura Y, Osuga Y, Koga K, Tajima T, Hirota Y, Hirata
T, et al. Selective increase in high molecular weight
adiponectin concentration in serum of women with
preeclampsia. J Reprod Immunol 2007;73:60–65.
Ouyang YQ, Li SJ, Zhang Q, Xiang WP, Shen HL, Chen HP,
et al. Plasma sFlt-1-to-PlGF ratio is correlated with
inflammatory but not with oxidative stress in Chinese
preeclamptic women. Arch Gynecol Obstet. 2009;280:91–7.
Ouyang Y, Chen H, Chen H. Reduced plasma adiponectin
and elevated leptin in pre-eclampsia. Int J Gynaecol Obstet
; 98: 110–14.
Ramsay JE, Jamieson N, Greer IA, Sattar N. Paradoxical
elevation in adiponectin concentrations in women with
preeclampsia. Hypertension 2003;42:891–4.
Kajantie E, Kaaja R, Ylikorkala O, Andersson S, Laivuori H.
Adiponectin concentrations in maternal serum: elevated in
preeclampsia but unrelated to insulin sensitivity. J Soc
Gynecol Investig 2005;12:433–9.
Naruse K, Yamasaki M, Umekage H, Sado T, Sakamoto Y,
Morikawa H. Peripheral blood concentrations of adiponectin,
an adipocyte-specific plasma protein, in normal pregnancy
and preeclampsia. J Reprod Immunol 2005;65:65–75
Nien JK, Mazaki-Tovi S, Romero R, Erez O, Kusanovic JP,
Gotsch F, et al. Adiponectin in severe preeclampsia. J Perinat
Med 2007;35:503–12.
Mazaki-Tovi S, Romero R, Vaisbuch E, Kusanovic JP, Erez
O, Gotsch F, et al. Maternal serum adiponectin multimers in
preeclampsia. J Perinat Med 2009;37:349–63.
J Ayub Med Coll Abbottabad 2009;21(3)
http://www.ayubmed.edu.pk/JAMC/PAST/Ali.pdf
Herse F, Bai Youpeng, Staff AC, Yong-Meid J, Dechend R,
Zhou Rong. Circulating and uteroplacental adipocytokine
concentrations in preeclampsia. Reprod Sci 2009;16:584–90.
Hendler I, Blackwell SC, Mehta SH, Whitty JE, Russell E,
Sorokin Y, et al. The levels of leptin, adiponectin, and
resistin in normal weight, overweight, and obese pregnant
women with and without preeclampsia. Am J Obstet
Gynecol. 2005; 193: 979–83.
Odden N, Henriksen T, Holter E, Grete Skar A, Tjade T, Morkrid
L. Serum adiponectin concentration prior to clinical onset of
preeclampsia. Hypertens Pregnancy 2006;25:129–42.
Marinoni E, Letizia C, Ciardo F, Corona G, Moscarini M, Di
Iorio R. Effects of prenatal betamethasone administration on
leptin and adiponectin concentrations in maternal and fetal
circulation. Am J Obstet Gynecol. 2008;199:141.e1–6
Mazaki-Tovi S, Kanety H, Sivan E. Adiponectin and human
pregnancy. Curr Diab Rep 2005;5:278–81.
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