LIVER DYSFUNCTION IN DENGUE INFECTION, AN ANALYSIS OF THE PREVIOUSLY PUBLISHED THAI CASES

Authors

  • Viroj Wiwanitkit

Abstract

Background: Dengue infection is a major vector-borne disease. The classical sings and symptomsof this infection include high fever, violent headache, chill and rash. However, there are a numberof atypical forms of dengue infection including those presented with liver dysfunction. However,there are only a few reports concerning the liver dysfunction among the patients with dengueinfections. Methods: Here, the author presents a summative study on the liver dysfunction and itsclinical correlation among Thai patients in the previous studies. A literature review on theprospective studies concerning liver function and dengue infection in Thailand was performed.Results: According to this study, there are 4 reports included covering 191 Thai pediatric patientswith dengue infection. The overall rate of liver dysfunction among 191 subjects is 34.6 % (66/191).The rate of liver dysfunction among the patients without shock (36/120) is not significant differentfrom those with shock. The rate of liver dysfunction in this study is considerable high, similar tothe previous reports from other developing Asian countries. In addition, about 8 % (5/66) thepatients with liver dysfunction developed hepatic encephalopathy. Conclusions: This can implythe importance of detection of abnormal high transaminase enzyme among the patients withdengue infection since the consequently developed hepatic encephalopathy can be expected.Key words: Dengue, Liver, Dysfunction

References

Thisyakorn U, Thisyakorn C. Diseases caused by

arboviruses--dengue haemorrhagic fever and Japanese B

encephalitis. Med J Aus 1994; 160(1): 22 - 6.

Guzman MG, Kouri G. Dengue: an update. Lancet Infect

Dis 2002; 2(1):33-42.

da Fonseca BA, Fonseca SN. Dengue virus infections. Curr

Opin Pediatr 2002;14(1):67-71.

Solomon T, Mallewa M. Dengue and other emerging

flaviviruses. J Infect 2001; 42(2):104-15.

Huerre MR, Lan NT, Marianneau P, Hue NB, Khun H,

Hung NT, et al. Liver histopathology and biological

J Ayub Med Coll Abbottabad 2007;19(1)

correlates in five cases of fatal dengue fever in

Vietnamese children. Virchows Arch 2001;438(2):107.

Punapanich W. Liver function test in patients with

dengue infection.Thai J Pediatr 1998; 37: 104-105.

Attavinijtrakarn P. Hepatic dysfunction in dengue

hemorrhagic fever in Paholpolpayuhasaena Hospital.

Thai J Pediatr 2000; 39: 265-276.

Ukarapol N, Wongsawasdi L. Hepatic involvement of

dengue hemorrhagic fever in pediatric patients. Thai J

Pediatr 2000; 39: 1-7.

Sattayapisan A. Hepatic dysfunction in DHF in Ranong

Hospital. Reg 11 Med J 2002; 16: 15-17.

Pancharoen C, Rungsarannont A, Thisyakorn U. Hepatic

dysfunction in dengue patients with various severity. J

Med Assoc Thai 2002; 85 (Suppl 1): S298-S301.

Mongkolsiri D. The liver function tests in dengue

hemorrhagic patients: a descriptive study at Sukhothai

Hospital. Reg 1 Med J 2001; 3: 11-21.

Wichmann O, Hongsiriwon S, Bowonwatanuwong C,

Chotivanich K, Sukthana Y, Pukrittayakamee S. Risk

factors and clinical features associated with severe dengue

infection in adults and children during the 2001 epidemic

in Chonburi, Thailand. Trop Med Int Health

;9(9):1022-9.

Chen HC, Lai SY, Sung JM, Lee SH, Lin YC, Wang WK,

et al. Lymphocyte activation and hepatic cellular

infiltration in immunocompetent mice infected by dengue

virus. J Med Virol 2004; 73(3):419-31.

Mohan B, Patwari AK, Anand VK. Hepatic dysfunction in

childhood dengue infection. J Trop Pediatr

;46(1):40-3.

Nguyen TL, Nguyen TH, Tieu NT. The impact of

dengue haemorrhagic fever on liver function. Res Virol

; 148(4):273-7.

Kuo CH, Tai DI, Chang-Chien CS, Lan CK, Chiou SS,

Liaw YF. Liver biochemical tests and dengue fever. Am J

Trop Med Hyg 1992;47(3):265-70.

Published

2007-03-01