Noreen Wadood, Muhammad Nisar, Abdul Rashid, Abdul Wadood, Gul- Nawab, Ayub Khan


Background: The present study was planned to observe the hypoglycaemic effect of the
Compound recipe’ a combination of traditional medicinal plants in normal and alloxan induced
diabetes mellitus. This study was performed to study the possible role of indigenous medicinal
plants in the regeneration of pancreatic b- cells and in treatment of insulin dependent diabetes
mellitus. Methods: The ‘Compound recipe’ was administered daily in doses of 400-mg/kg body
weight to normal and alloxan induced diabetic rabbits for a period of 4 months. The blood glucose
and serum insulin levels were estimated before and 1, 2, 3 and 4 months after the administration of
the extract. Results: The extract exerted a significant (P<0.05) hypoglycemic effect in alloxan
diabetic rabbits. The hypoglycemic effect was not significant (P> 0.05) in normal rabbits. The
extract exerted a significant (P<0.05) increase in insulin levels in alloxan diabetic rabbits. The
effect on the insulin levels was not significant (P> 0.05) in normal rabbits. The doses used did not
show acute toxicity or result in behavioral changes. Conclusion: From this study it may be
concluded that the Compound recipe causes an increase in serum insulin levels in alloxan induced
diabetic rabbits possibly due to regeneration of pancreatic b cells.
Keywords : Compound recipe, hypoglycemic effect, alloxan-induced diabetes, serum insulin.

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