C REACTIVE PROTEIN LEVELS AS A MARKER OF CORONARY HEART DISEASE IN MIDDLE AGED INDIVIDUALS

Nadia Haleem, Zahid Irfan Marwat, Shazia Tauqeer, Sarwat Abbasi

Abstract


Background: coronary heart disease is multifactorial inflammatory process which involves the accumulation of lipid macrophages and intimal plaques in smooth muscle cell in large and medium sized arteries. C reactive protein (CRP) which is an inflammatory marker is considered as global risk assessment for coronary heart disease. The objective of study is to determine the CRP level as risk marker in coronary heart disease in middle aged individuals. Methods: This cross sectional study was conducted in Hayatabad medical complex Peshawar and Rehman Medical Institute Peshawar. On the basis of predesigned questionnaire, 100 middle aged individuals of age 40-60 years and 50 normal subjects of same age were questioned by taking consent. Data was collected and analysed by SPSS-15. Results: It was founded that 74% of patients have higher values of CRP and 4% have high values of CRP in controls. The t-test applied at 95% confidence interval with mean difference of 22.096+2.36 of CHD individuals and 1.288±1.70 of control group. P-value was 0.001 which is found to be significant. Conclusion: It was observed that CRP has higher association with CHD.


Full Text:

PDF

References


Cardiovascular disease. in: Kumar PJ, Clark ML. Kumar & Clark’s clinical medicine. Edinburgh; New York: Saunders Elsevier; 2009.p.743–7.

Diseases of the coronary arteries. in: Julian DG, Cowan JC, McLenachan JM, editors. Cardiology. 8th ed. Edinburgh; New York: Elsevier Saunders; 2005.p.78–5.

Cardiovascular diseases. in: Ballinger A, Patchett S. Pocket essentials of clinical medicine. 4th ed. Saunder Elsevier, New York 2007.p.43–7.

Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S, Murphy A. Growing Epidemic of Coronary Heart Disease in Low- and Middle Income Countries. Curr Probl Cardiol 2010;35(2):72–15.

The cardiovascular system. in: Chandrasoma P, Taylor CR, editors. Concise pathology. 3rd ed. Mc Graw Hill, New York 2001.p.315–22.

Kruse AL, Luebbers HT, Grätz KW. C-reactive Protein levels: A prognostic marker for patients with head and neck cancer. J Head Neck Oncol 2010;2:21.

Burtis CA, Ashwood ER, Bruns DE, Tietz NW, editors. Apolipoproteins and other cardiovascular risk factors: in: Tietz textbook of clinical chemistry and molecular diagnostics. 4ed. St. Louis, Mo: Elsevier, Saunders; 2006.962–7.

Casas JP, Shah T, Hingorani AD, Danesh J, Pepys MB. C-reactive protein and coronary heart disease: a critical review. J Intern Med 2008;264(4):295–314.

Hingorani AD, Shah T, Casas JP, Humphries SE, Talmud PJ. C-reactive protein and coronary heart disease: predictive test or therapeutic target?. Clin chem 2009;55(2):239–55.

Patel VB, Robbins MA, Topol EJ. C-reactive protein: A Golden marker for inflammation and coronary heart disease. Cleve Clin J Med 2001;68(6):521–24, 527–34.

Danish J, Wheeler JG, Hirschfield GM, Eda S, Erricksdotter G, Rumley A, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004;350(14):1387–97.

Ridker PM. Clinical application of CRP for cardiovascular disease detection and prevention. Circulation 2003;107(3):363–9.

Cushman M, Arnold AM, Psaty BM, Manolio TA, Kuller LH, Burke GL, et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women The Cardiovascular Health Study. Circulation 2005;112(1):25–31.

Braunwald E. Atlas of internal medicine. Philadelphia: Current Medicine LLC; 2007.

Thakur S, Gupta S, Parchwani H, Shah V, Yadav V. Hs-CRP - A Potential Marker for Coronary Heart Disease. Indian J Fundam Appl Life Sci 2011;1(1):1–4.

Irfan G, Ahmed M. High sensitivity C-reactive Protein concentration and angiographic character of coronary lesion. J Ayub Med coll Abbottabad 2008;20(3):100–3.

Khan DA, Ansari WM. Saleem S, Khna FA. Reference value for high sensitivity CRP in northern Pakistan population. Pak Armed Forces Med J 2009;59(4):257–8.

Kulsoom B. Hasnain SH. Association of Serum C-Reactive Protein and LDL:HDL with Myocardial Infarction. J Pak Med Assoc 2006;56(6):318–22.


Refbacks

  • There are currently no refbacks.


Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]