ADVERSE EFFECTS OF PYRAZINAMIDE IN PAKISTANI PATIENTS

Authors

  • Ronaq Zaman
  • Shaukat Ali Orakzai

Abstract

Abstract: The effect of Pyrazinamide on Liver and Kidney functiontests as well as on Serum and Urinary Uric Acid levels was studiedin Patients with Pulmonary Tuberculosis. A rise in Serum totaland direct bilirubin, SGOT and SGPT was observed. No significantrise was observed in alkaline phosphatase concentration. One outof fifteen patients developed Jaundice.A rise in Serum Uric Acid, Serum Creatinine concentrationduring drug therapy was associated with a fall in UrinaryExcretion of Uric Acid and Creatinine.

References

Mitchison, D.A. Basic Mechanism of Chemotherapy. Chest. 1979; 76 (6 Suppl):

Ellord, G.A. Absorption, metabolism and excretion of Pyrazinamide in man.

Tubercle. 1969; 50 : 144.

Ellord, G.A. and Haslam, R.M. Observation on the reduction of renal elimination

or urate in man caused by administration of Pyrazinamide, Tubercle. 1976; 57 :

Yu, T.F., Burger. L., Stove, D.J., Wolf. J. and Gutman, A.B. Effect of Pyrazinamide

and Pyrazionic acid on urate clearance and other discrete renal functions.

Proceedings of the experimental biology and Medicine. 1957; 96 : 264.

McDermott, W., Ormond, L., Muschenheim, C., Deuchle, K. and McCune, R.M.

Pyrazinamide-Isoniazid in Tuberculosis. American Review of tuberculosis. 1954;

: 319.

Bpron, D.N. and Bell, J.L. Serum enzyme changes in patients receiving antituberculosis therapy with Rifampicin or p-aminosalicyclic acid, plus Isoniazid and

Streptomycin. Tubercle. 1974; 55 : 115.

United States Public Health Service. Hepatic toxicity of Pyrazinamide used with

Isoniazid in Tuberculosis Patients. A U.S. Public Health Service tuberculosis

therapy trial. American Review of Resp. diseases. 1959; 80 : 371.

Velu, S, Dawson, J.J.Y., Devadatta, S., Fox, W., Kulkarni, K.G., Mohan, K., Rama

Krishnam, C.V. and Stott, H. A controlled comparison of streptomycin plus

pyrazinamide and streptomycin plus PAS in the retreatment of patients excreting

Isoniazid-resistant organism.

East African/British Medical Research Councils. Streptomycin Plus PAS plus

Pyrazinamide in retreatment of Pulmonary tuberculosis in East Africa. Second

Report. Tubercle. 1973; 54 : 283.

Tuberculosis Chemotherapy Centre, Madras. A controlled comparison of a twice

weekly and three once-weekly regimens in initial treatment of pulmonary tuberculosis. Bulletin of World health organisation. 1970; 43 : 143.

Hare, R.S. Endogenous creatinine in Serum and Urine. Proc. Soc. Exp. Biol. Med.

; 74 : 148.

Henery, R.J., Sobel, C. and Kim, J.A. Modified Carbonate-Phosphatungstate

methods for the determination of Uric acid and Comparison with Spectrophotometric uricage methods. Am. J. Clin. Pathol. 1957; 28 : 645.

Malloy, H.T. and Evelyn, J.A. (1973). In Annino, J.S., Giese, R.M. Clinical Chemistry. 4th Ed., Little Brown and Co., Boston. 1976; 217-22.

Reitman, S. and Frankel, S. (1957). In Annino, J.S., and Giese, R.W. Clinical

Chemistry. 4th Ed., Little Brown and Co., Boston. 1976; 258-261.

Bessey, O.A., Lowery, O.H. and Brock, M.J. (1946). In Annino, J.S and Giese, R.W.

Clinical Chemsitry 4th Ed., Little Brown and Co., Boston. 1976; 252-257.

Hong Kong Tuberculosis Treatment Services/British Medical Research Council.

Adverse reactions to shortcourse regimens containing streptomycin, Isoniazid,

Pyrazinamide and Rifampicin in Hong Kong. Tubercle. 1979; 57 : 81.

Ilyas Khan, M. Adverse reactions of antituberculosis drugs with special reference

to Rifampicin and Pyrazinamide. JPMA 1987; 37 : 76.

Issue

Vol. 1 No. 2 (1988): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABA

Section

ORIGINAL ARTICLE

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.