CORRELATION OF SERUM CARBAMAZEPINE AND GAMMA GLUTAMYLE TRANSFERASE IN ADULT EPILEPTICS

Akhtar Hamid Malghani, Muhammad Tayyab, Allah Ditta, Haroon Rashid Chaudhry, Mohammad Saleem, Haleem -ud- Din, Naseer Ahmad Chaudrhy

Abstract


A study was conducted to determine serum carbamazepine (CBZ) levels by high performance liquid
chromatography (HPLC) and gamma glutamyl transferase (GGT) activity in 40, already diagnosed
epileptic patients (20 males and 20 females) on CBZ therapy for more than six months. Twenty normal
healthy controls (JO males and 10 females) were included in the study. The mean f standard deviation of
CBZ level in all subjects, males (young and old, females young and old) were 4.2±2.76, 3.47±2.15,
3.65±3.21 and 4.80±^3.27, 3.86 f 3.65 ug/ml respectively.
While the GGT level in all the subjects were 50.57±23.36, in male 52.42 ±23.68 IU/L and in female
48.5±23.28 IIJ/L. It was observed that the serum GT activity> in relation to daily- dosage of CBZ was
more in old than young groups. The comparison between daily dosage and CBZ was weakly positive (r-
0.2951) while serum CBZ versus serum GGT activity (0.09820), shows no correlation. Hence it was
concluded that there is no significant correlation between serum CBZ level and serum GGT activity. To
avoid toxic effects of drug over dosage and to obtain therapeutic results drug monitoring is essential.

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References


Chaudhry MR. History of epilepsy. Lahore: Pakistan

Psychiatric Research Centre. 1996.

Tomson T. Interdosage fluctuations in plasma

carbamazepine concentration determine intermittent

side effects. Arch Neurol 1984; 41: 830-34.

Miles MV, Lawless ST, Tennison MB. Rapid loading

of critically III patients with carbamazepine

suspension. Pediatrics 1990: 86:263-66.

Shorvan SD. Epilepsy: A general practice perspective.

National Society for Epilepsy Research Group London.

: 1-58.

Mucklow JC. Therapeutic drug monitoring. Medicine

International 1992; 5: 4244-48.

Marin DB, Greenwald BS. Carbamazepine for

aggressive

agitation in demented patients during nursing care. Am.

J. Psychiatry 1989; 146(6): 805.

Bertilsson L, Hojer B. Tybring G, Osterloh J, Rave A.

Auto-induction of carbamazepine metabolism in

children examined by a stable isotope technique. Clin.

Pharmocol. Ther. 1980; 27(l):83-88.

Cochran EB, Massey KL, Phelps SJ. A rapid, noninstrumented whole blood carbamazepine assay for

pediatric patients. J. Pediatr. 1990; 116(2):307-10.

Sheikh SA. Correlation of serum carbamazepine with

GGT in children and adolescence by HPLC [Thesis].

Lahore: University of the Punjab, 1996.

Aldenhovel HG. The influence of long-term

anticonvulsant therapy with diphenyl hydantious and

carbamazepine on serum gammaglutamyl transferase,

asparate aminotransferase, alanine

aminotransferase and alkaline phosphatase Arch

Psychiatry Neurol Sci 1988; 237: 312-16.

Okesina AB, Donaldson D, Lascelles PT. Serum

gammaglutamyl transferase activities in epileptic

patients receiving carbamazepine monotherapy. Ann

Clin Biochem 1991; 28:207-8.

Huf R, Schain RJ. Long-term experiences with

carbamazepine (tegretol) in children with seizures. J.

Pediatr 1980; 97(2):310-12.

Donohoe NV. Epilepsies of childhood. 2nd Ed.

London: Butterworth’s, 1985:201-13.


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