Akhtar Hamid Malghani, Muhammad Tayyab, Allah Ditta, Haroon Rashid Chaudhry, Mohammad Saleem, Haleem -ud- Din, Naseer Ahmad Chaudrhy


A study was conducted to determine serum carbamazepine (CBZ) levels by high performance liquid
chromatography (HPLC) and gamma glutamyl transferase (GGT) activity in 40, already diagnosed
epileptic patients (20 males and 20 females) on CBZ therapy for more than six months. Twenty normal
healthy controls (JO males and 10 females) were included in the study. The mean f standard deviation of
CBZ level in all subjects, males (young and old, females young and old) were 4.2±2.76, 3.47±2.15,
3.65±3.21 and 4.80±^3.27, 3.86 f 3.65 ug/ml respectively.
While the GGT level in all the subjects were 50.57±23.36, in male 52.42 ±23.68 IU/L and in female
48.5±23.28 IIJ/L. It was observed that the serum GT activity> in relation to daily- dosage of CBZ was
more in old than young groups. The comparison between daily dosage and CBZ was weakly positive (r-
0.2951) while serum CBZ versus serum GGT activity (0.09820), shows no correlation. Hence it was
concluded that there is no significant correlation between serum CBZ level and serum GGT activity. To
avoid toxic effects of drug over dosage and to obtain therapeutic results drug monitoring is essential.

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