METABOLIC EFFECTS OF ALCOHOLISM AND ITS RELATIONSHIP WITH ALCOHOLIC LIVER DISEASE
Abstract
Background. Chronic and excessive ethanol consumption is associated with cellular proliferation, fibrosis, cirrhosis and cancer ofliver. It was planned to study the effect of alcohol on different biochemical parameters as distribution of these parameters may leadto several complications in gastrointestinal tract, liver, kidney, brain etc. Methods: 50 alcoholic males and 20 normal subject (withno history of alcohol) with an age ranges 30-45 years were included in the study. Biochemical parameters related to liver wereestimated.by standard kit. Besides, ions and electrolytes were also determined by standard kit and flame photometer). Results: Itwas observed that level of alkaline phosphatase, alanine transferase, protein and globulin were significantly increased as comparedto normal subjects. Besides, ions like calcium and phosphate were significantly decreased. On the other hand, the level of potassiumand magnesium was significantly decreased as compared to normal subjects. Electrophoresis shows a protein of 100 Kda is presentin the patient’s sample as compared to control subjects. Conclusion: It is therefore concluded that abnormal biochemical functionof liver in alcoholism can lead to several complications, hence further research is needed to reach a definite conclusion.References
Serov VV. Does alcoholic chronic hepatitis exist1 Arkh Palol
61:54-7
Wang XD. Chronic alcohol intake interferes with retinoid
metabolism and signaling Nutr Rev 1999.57:51-9
Eaton S. Record CO. Bartlett K, Multiple biochemical effects in
the pathogenesis of liver damage in the alcoholic fatty liver bur J
Clin Invest 1997,27 719-22
Worm an HJ, American Liver Foundation. Cedar Grove. NJ
, 1998
Bunout D. Nutritional and metabolic effects of alcoholism, their
ationship with alcoholic fiver disease Nutrition 1999.
I5 58J-9
Boyer DJ, Ackerman GP and Toro G Determination Io ALT,
calcium magnesium, phosphorous, protein, albumin and AG ration
by enzymatic, dye, Fisk and sub arrow and Biuret method. 8th ed.
St. Louis. 1997:400-500
King and King Microanalysis in Medical Biochemistry by Wotton
TDP. Ed Churchill, Livingstone. Edinburgh and London. 1982
-6
Laemmli UK Cleavage of structural proteins during assembly of
head of bacteriophage T4 Natural London1997:227:680-5
Bairoch A and Apwciler R (1997). The Swiss Port Protein
Sequence Data Bank and its supplement TRL MB Uric Acid Res
:31-6
Thulstrup AM. Sorensen HT Steffens’s Ml. Vilstup Hl. Launtzen
Change liver – derived and self-employed consumption A oneyear follow-up study m (Denmark Scand) Gastroenterol I W 34
-93
Korounan S. Hakkak R. Ronis MJ, Shdnuti SR Waldron J.
Ingelman-Sunberg M. Badger TM Diet and risk of ethanol induced
hepatotoxic. carbohydrate-fat relationship Toxicol Set 1999. 47
-7
Khursheed R and Baseer A. Ate km cholesterol values associated
with cancer. J Armed Med Forces. 1992
Barona t and Lieber CS Effect of ethanol on lipid metabolism i
Lipid Res 1979 HI 289-31?
Murray RK, Grander DK, Mayes RA and Rodwell VW Harper's
Biochemistry Appleton and Lange Publications SA Maleo 1998,
Pp 577
Zubay G Biochemistry. 2nd ed MacMillan Pub Co New York.
Pp 616.668
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
