CRANIOFACIAL ALTERATIONS IN ADULT RATS AFTER ACUTE PRENATAL ALCOHOL EXPOSURE

MUHAMMAD ISMAIL, MUHAMMAD ZAHOOR JANJUA

Abstract


Background: Exposure during pregnancy to alcohol (ethanol) produces a number of adverse effects. One of them) is
fetal alcohol syndrome. The hallmark in fetal alcohol syndrome (FAS) is craniofacial dimorphisms and the changes
in craniofacial measurement are dependent on the alcoholic dose and its time of exposure. Since prenatal ethanol
exposure can alter craniofacial development in rodents and reliably produce long-term behavioral effect in them, the
present study was designed to extend the same changes in the Sprague Dawley species. Methods: The albino rat was
studied to determine whether gestational exposure to ale tol (Ethanol) produces permanent craniofacial effect On
gestational day (GD7-I0) 25% ethanol was injected intraperitonealy to pregnant rats. Various dimensions for skull and
face of adult male rats were taken. Results: Both vertical and coronal dimensions were altered in the exposed animals.
Conclusions: This study demonstrates that exposure to ethanol on a critical gestational period produces permanent
craniofacial defects.

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