PLASMA SURFACTANT PROTEIN-A LEVELS IN HEALTHY SUBJECTS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

Authors

  • Hafiz Muhammad Waseem University of Health Sciences, Lahore http://orcid.org/0000-0001-6923-5981
  • Rida Ajmal Khan Azra Naheed Medical College, Lahore
  • Khalid Parvez Lone University of Health Sciences, Lahore

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is the leading cause of morbidity and mortality across the globe. Currently, there is a dearth of biomarkers which can accurately diagnose and evaluate the prognosis of the disease. Systemic Surfactant Protein- A (SP-A) levels are generally higher in smokers compared to non-smokers as well as elevated in COPD patients as compared to controls. The objective of the study was to estimate and compare plasma surfactant protein-A levels in male and female COPD patients and healthy subjects and to evaluate the role of SP-A as a possible bio-marker for COPD patients. Methods: A Comparative study, conducted at the department of Physiology & Cell Biology, University of Health Sciences, Lahore between August 2013 and April 2015. A total of 84 subjects of both sexes between 30-80 years of age were included in this study. Subjects were taken from local community and were divided into four groups (A- D). COPD was diagnosed on the basis of relevant history and spirometry showing post bronchodilator FEV1/FVC <0.70. Results: Plasma SP-A levels were not different between controls and COPD patients and between male and female COPD patients. However, SP-A levels were directly correlated with cotinine levels (r= 0.503, p=0.001). Female patients were usually more symptomatic than males and developed COPD at an earlier age compared with male patients. Conclusion: Plasma SP-A levels were not significantly different between groups. Plasma cotinine levels (an indication of the tobacco use) were positively correlated with plasma SP-A levels in study subjects. Female patients developed COPD at an early age compared to male counterparts with similar tobacco exposure.Keywords: Chronic Obstructive Lung Disease, Surfactant Protein A, Cotinine, Spirometry, Smoking

Author Biographies

Hafiz Muhammad Waseem, University of Health Sciences, Lahore

PhD Scholar, Department of Physiology & Cell Biology, University of Health Sciences, Lahore.

Rida Ajmal Khan, Azra Naheed Medical College, Lahore

Assistant Professor, Department of Physiology, Azra Naheed Medical College, Lahore.

Khalid Parvez Lone, University of Health Sciences, Lahore

Professor & Head of Department, Department of Physiology & Cell Biology, University of Health Sciences, Lahore

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Published

2020-01-28