ATYPICAL PRESENTATION OF MYOSITIS OSSIFICANS PROGRESSIVA IN A 63-YEAR-OLD WOMAN: OLDEST REPORTED CASE FROM PAKISTAN

Authors

  • Sumaira Nawaz Shifa International Hospital
  • Tafiya Erum Kamran Shifa College of Medicine
  • Seyreen Faisal Shifa College of Medicine
  • Rida Inam Shifa College of Medicine
  • Moaz Azhar Shifa College of Medicine

Keywords:

surgery, myositis, ossifying lesion, calcification, progressiva

Abstract

Myositis Ossificans (MO) is a heterotrophic ossifying lesion of benign aetiology. It typically presents as a solitary, well-defined lesion. This disease is most commonly seen in skeletal muscles and can often also be seen in subcutaneous fat. Myositis Ossificans Progressiva (MOP) is a hereditary disorder. There is limited published literature available regarding this disease and its presentation. However, it seems that there are exceptions to when this disease can present. In this paper, we detail an interesting case of a 63-year-old female patient who presented to the OPD as a late-onset progressive MO with no known aetiology. Due to limited erudition on the presentation and precluding factors of the disease at this age, a diagnosis was made after assiduous care, diligence, and time. An extensive literature search has ascertained this to be the oldest patient presenting as Atypical MOP worldwide and the first reporting of Adult-Onset MOP in the sub-continent.

Author Biographies

Sumaira Nawaz, Shifa International Hospital

Consultant Surgery

Tafiya Erum Kamran, Shifa College of Medicine

Medical Student

Seyreen Faisal, Shifa College of Medicine

medical student

Rida Inam, Shifa College of Medicine

Medical student

Moaz Azhar, Shifa College of Medicine

Medical student

References

1. Walczak BE, Johnson CN, Howe BM. Myositis ossificans. J Am Acad Orthop Surg 2015;23(10):612–22.

2. Sferopoulos NK, Kotakidou R, Petropoulos AS. Myositis ossificans in children: a review. Eur J Orthop Surg Traumatol 2017;27(4):491–502.

3. Rehman N, Sadashiva H, Madakshira MG, Raman DK. Non-traumatic myositis ossificans. Autops Case Rep 2021;11:e2021316.

4. Talbi S, Aradoini N, Mezouar IE, Abourazzak FE, Harzy T. Myositis ossificans progressive: case report. Pan Afr Med J 2016;24:264.

5. Lacout A, Jarraya M, Marcy PY, Thariat J, Carlier RY. Myositis ossificans imaging: keys to successful diagnosis. Indian J Radiol Imaging 2012;22(1):35–9.

6. Meyers C, Lisiecki J, Miller S, Levin A, Fayad L, Ding C, et al. Heterotopic ossification: a comprehensive review. JBMR Plus 2019;3(4):e10172.

7. Brance ML, Cóccaro NM, Casalongue AN, Durán A, Brun LR. Extensive progressive heterotopic ossification post-Covid-19 in a man. Bone 2022;155:116287.

8. El Bardouni A, Boufettal M, Zouaidia F, Kharmaz M, Berrada MS, Mahassini N, et al. Non-traumatic myositis ossificans circumscripta: a diagnosis trap. J Clin Orthop Trauma 2014;5(4):261–5.

9. Akesson LS, Savarirayan R. Fibrodysplasia ossificans progressiva. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2021.

10. Scarlett RF, Rocke DM, Kantanie S, Patel JB, Shore EM, Kaplan FS. Influenza-like viral illnesses and flare-ups of fibrodysplasia ossificans progressiva. Clin Orthop Relat Res 2004;(423):275–9.

11. Jayasundara JA, Punchihewa GL, de Alwis DS. An unusual case of adult onset progressive heterotopic ossification suggesting a variant form of fibrodysplasia ossificans progressiva. Singapore Med J 2012;53(4):e83–6.

12. Cunningham CM, Royeca JM, King SW, Pandit H. Late-onset fibrodysplasia ossificans progressiva with atypical presentation: a case report. Case Rep Womens Health 2019;23:e00134.

13. Lewis D. Myositis ossificans. JAMA 1923;80(18):1281–7.

14. Pignolo RJ, Shore EM, Kaplan FS. Fibrodysplasia ossificans progressiva: clinical and genetic aspects. Orphanet J Rare Dis 2011;6:80.

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Published

2026-09-02

How to Cite

1.
Nawaz S, Kamran TE, Faisal S, Inam R, Azhar M. ATYPICAL PRESENTATION OF MYOSITIS OSSIFICANS PROGRESSIVA IN A 63-YEAR-OLD WOMAN: OLDEST REPORTED CASE FROM PAKISTAN. J Ayub Med Coll Abbottabad [Internet]. 2026 Sep. 2 [cited 2026 Sep. 10];38(1):94-7. Available from: https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/13756