• Kaweeta Kumari
  • Naresh Kumar Seetlani
  • Rehana Akhter


Background: Viral hepatitis is a global problem affecting millions of people including pregnant females. Viral hepatitis during pregnancy is associated with both maternal and neonatal mortality and morbidity. This study was an attempt to assess the seropositive status of hepatitis-B and C infection among pregnant women in Karachi, Pakistan. Methods: This cross sectional observational study was conducted at Sir Syed College of Medical Sciences and Trust Hospital, Karachi from January to September 2012. Patients were recruited by consecutive sampling. At the booking visit, blood was drawn and tested for HbsAg and Anti HCV by Eliza method. Results: Among the screened population, 2% were reactive for HBV and 13.3% were found reactive for HCV. All HbsAg and HCV positive pregnant patients had one or more than one delivery. Conclusion: In our study sample, high frequency of HBV and HCV is suggestive of the importance of antenatal screening of these viral diseases, which has impact on the mother as well as the new born baby. HCV was more common as compared to HBV which is quite alarming.Keywords: Hepatitis-B Virus, Hepatitis-C Virus, Pregnancy, Liver disease, prevalence, risk factor.


Ugbebor O, Aigbirior M, Osazuwa F, Enabudoso E, Zabayo O. The prevalence of hepatitis-B and C viral infections among pregnant women. N Am J Med Sci 2011;3(5):238–41.

Baha W, Foullous A, Dersi N, They-they TP, Alaoui KE, Nourichafi N, et al. Prevalence and risk factors of hepatitis-B and C virus infections among the general population and blood donors in Morroco. BMC Public Health 2013;13:50.

Waheed Y, Saeed U, Safi SZ, Chaudhry WN, Qadri I. Awareness and risk factors associated with barbers in transmission of hepatitis-B and C from Pakistani population: barber’s role in viral transmission. Asian Biomed 2010;4(3):435–42.

Ali M, Idrees M, Ali L, Hussain A, Ur Rehman I, Saleem S, et al. Hepatitis-B virus in Pakistan: a systematic review of prevalence, risk factors, awareness status and genotypes. Virol J 2011;8:102.

Waheed Y, Shafi T, Safi SZ, Qadri I. Hepatitis-C virus in Pakistan: a systematic review of prevalence, genotypes and risk factors. World J Gastroenterol 2009;15(45):5647–53.

Salam A, Yasinzai MM, Taj MH, Das N, Mohammad A. Prevalence of hepatitis-B surface antigen positive cases. Professional Med J 2003;23–5.

Gasim GI, Murad IA, Adam I. Hepatitis-B and C virus infections among pregnant women in Arab and African countries. J Infect Dev Ctries 2013;7(8):566–78.

Ali SA, Donahue RMJ, Qureshi H, Vermund SH. Hepatitis-B and hepatitis-C in Pakistan: prevalence and risk factors. Int J Infect Dis 2009;13(1):9–19.

Mehta KD, Antala S, Mistry M, Goswami Y. Seropositivity of hepatitis-B, hepatitis-C, syphilis, and HIV in antenatal women in India. J Infect Dev Ctries 2013;7(11):832–7.

Khattak ST, Ali Marwat M, Khattak Iu, Khan TM, Naheed T. Comparison of frequency of hepatitis-B and hepatitis-C in pregnant women in urban and rural area of district Swat. J Ayub Med Coll Abbottabad 2009;21(2):12–5.

Rana GE, Akmal N, Akhtar N. Prevalence of hepatitis-B in pregnant females. Ann King Edward Med Uni 2006;12(2):313–6.

Kulsoom Al. Frequency of hepatitis-B and C carrier state in obstetric and gynaecological patients at teaching hospital Khairpur. Med Channel 2012;19(2):61–3.

Amin J, Yousuf H, Mumtaz A, Iqbal M, Ahmed R, Adhami SZ et al. Prevalence of hepatitis-B surface antigen and anti hepatitis-C virus among general population in Lahore. Professional Med J 2004;11:334–7.

Yousfani S, Mumtaz F, Memon A, Memon MA, Sikandar R. Antenatal screening for Hepatitis-B and C virus carrier state at a University Hospital. J Liaquat Uni Med Health Sci 2006;24–7.

Taseer IU, Ishaq F, Hussain L, Safdar S, Mirbahar AM, Faiz SA. Frequency of anti-HCV, HBsAg and related risk factors in pregnant women at Nishtar Hospital, Multan. J Ayub Med Coll Abbottabad 2010;22(1):13–6.

Ghias M, Pervaiz MK. Identification of epidemiological risk factors for hepatitis-C in Punjab, Pakistan. J Ayub Med Coll Abbottabad 2009;21(2):156–61.

Majeed Z, Manzur MA. Prevalence of hepatitis-B and hepatitis-C viral infection in the rural population of Rahim Yar Khan. J Sheikh Zayed Med Coll 2012;3(2):310–12