COMPARISON OF SOLIFENACIN AND MIRABEGRON FOR THE TREATMENT OF OVERACTIVE BLADDER

Authors

  • Muhammad Nasir Jamil Department of Urology, Ayub Medical College, Abbottabad
  • Sadia Irum Department of Gynae/Obs, Ayub Medical College Abbottabad
  • Ehsan ul Islam Department of Urolog, yAyub Medical College Abbottabad

Keywords:

Overactive Bladder, Mirabegron, Urgency, Solifenacin

Abstract

Background: Overactive bladder is mostly treated with a combination of behavioural interventions and commonly prescribed anti-muscarinic medication therapy, including solifenacin, which has considerable side effects and lowers the quality of life. Mirabegron relaxes the detrusor muscle and is a recently approved drug for the treatment of OAB. This study examined the effectiveness and safety of two medications, solifenacin and mirabegron. Methods: This study was a comparative cross-sectional study conducted at Sami Medical Center, Abbottabad for a period of 6 months from August 2022 to January 2023. Female patients of aged ≥18 years with symptoms of OAB were enrolled. Results: Current study showed that the average age of patients was 37.47±12.48 years in Group S and 39.93±7.93 in Group M. The population consists of 60 (100%) females. After 4 weeks of follow up dizziness, dry mouth, constipation hypertension and blurred vision were found insignificant between both groups with p-values of 0.312, 0.161, 0.076, 0.076, and 0.313 respectively. OABSS score improved significantly and after therapy 4.20±1.32 in Group S and 3.43±1.13 in Group M. There was no significant difference in frequency of treatment withdrawal p-value 0.150. Conclusion: When it comes to relieving symptoms of OAB, both solifenacin and mirabegron are effective. The OABSS improved with both drugs; however, mirabegron was associated with fewer treatment-related adverse events. We advocate using mirabegron as the first-line treatment. Solifenacin can be utilized if patients are no longer getting the desired effects from Mirabegron.

Author Biographies

Muhammad Nasir Jamil, Department of Urology, Ayub Medical College, Abbottabad

Department of Urology, Ayub Medical College, Abbottabad

Sadia Irum, Department of Gynae/Obs, Ayub Medical College Abbottabad

 

Ehsan ul Islam, Department of Urolog, yAyub Medical College Abbottabad

 

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Additional Files

Published

2023-04-16

Issue

Vol. 35 No. 2 (2023): JOURNL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

ORIGINAL ARTICLE

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Copyright (c) 2023 Muhammad Nasir Jamil, Sadia Irum, Ehsan ul Islam

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