CORRELATION OF PRE-TRANSPLANT MELD SCORE WITH 30 AND 60 DAYS’ MORTALITY IN PATIENTS OF LIVER TRANSPLANT

Authors

  • Faryal Riaz Khan Khan Pak Emirates Military Hospital Rawalpindi
  • Rao Saad Ali Khan Pak Emirates Military Hospital, Rawalpindi-Pakistan
  • Khawar Shabbir Pak Emirates Military Hospital, Rawalpindi-Pakistan
  • Asim Shehzad Foundation University Medical College, Rawalpindi-Pakistan
  • Fuad Ahmad Siddiqi Combined Military Hospital, Rawalpindi-Pakistan
  • Zara Riaz Khan Pakistan Institute of Medical Sciences, Islamabad-Pakistan
  • Salahuddin DHQ Hospital, Haripur-Pakistan
  • Muhammad Bilal Khattak Hayatabad Medical Complex, Peshawar-Pakistan

Abstract

Background: The Model for End-Stage Liver Disease (MELD) score, introduced in 2002 by the United Network for Organ Sharing (UNOS), is a vital tool for predicting mortality for liver transplant candidates. Comprising serum creatinine, serum bilirubin, and international normalized ratio (INR), the MELD score includes kidney, liver, and coagulation pathway function, providing a comprehensive prognostic tool. Recent studies suggest broader prognostic implications, extending beyond organ allocation. Despite its benefits, around 15%-20% of patients may not experience accurate survival predictions. Methods: This retrospective single-center study, covering January 2016 to September 2023 with 87 patients, explores the correlation between pre-transplant MELD scores and 30 to 60-day post-transplant survival. Results: Our analysis reveals no significant impact of MELD scores on survival during this period, challenging existing literature (p=0.068). The study underscores the need for nuanced risk assessment beyond MELD scores, considering diverse clinical scenarios and patient-specific variables. Conclusion: Our findings contribute to refining predictive models and advocate for larger-scale investigations, emphasizing a holistic approach to optimize liver transplantation outcomes.

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Published

2024-09-08

Issue

Vol. 36 No. 3 (2024): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

ORIGINAL ARTICLE

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Copyright (c) 2024 Faryal Riaz Khan Khan, Rao Saad Ali Khan, Khawar Shabbir, Asim Shehzad, Fuad Ahmad Siddiqi, Zara Riaz Khan, Salahuddin

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