ROLE OF AUTOLOGOUS NANOFAT GRAFTING IN THE TREATMENT OF POST ACNE AND POST BURN SCARRING OF THE FACE
Keywords:
nano fat; fat grafting; scars; stem cell.Abstract
Background: Post acne and post burn facial scarring are more common in young generation leading to disfigurement and unpleasing result. These scars have major aesthetic, functional, and social effects on the affected person. Aim of the study was to establish the role of Autologous Nanofat grafting in treating post acne & post burn facial scarring in terms of pleasing aesthetic appearance of face & patient satisfaction. Methods: A total no. of 24 patients with mean age of 23 years was enrolled in the study. Thirteen patients were of post acne face scarring and 11 patients were suffering from post-burn face scarring. There were 10 male and 14 female patients. All patients were treated with Nanofat grafting with an average of 3 sessions at an interval of 4–6 weeks. The results were assessed after 6 months from the last session by comparison of pre procedure & post procedure pictures and patient satisfaction. Results: Scars started improving after first session of Nanofat grafting and significant improvement in the scars was noted after 3rd session in terms of pigmentation, scar thickness and softness. Overall appearances of the scar were aesthetically improved a lot with a higher patient satisfaction rate. Conclusion: Autologous Nanofat grafting is a potential effective treatment modality for post-acne and post burn facial scarring with a good aesthetic outcome and higher patient satisfaction rate.References
Levine E, Degutis L, Pruzinsky T, Shin J, Persing JA. Quality of life and facial trauma: Psychological and body image effects. Ann Plast Surg 2005;54(5):502–10.
Reish RG, Eriksson E. Scars: A review of emerging and currently available therapies. Plast Reconstr Surg 2008;122(4):1068–78.
Alster TS, Lupton JR. Lasers in dermatology. An overview of types and indications. Am J Clin Dermatol 2001;2(5):291–-303.
Neuber GA. Fetttransplantation. Chir Kongr Verhandl Deutsche Gesellschaft fur Chirugie. Chirurgie 1893;22:66.
Coleman SR. Structural fat grafting: more than permanent filler. Plast Reconstr Surg 2006;118(3 Suppl):108S–20.
James IB, Coleman SR, Rubin JP. Fat stem cells and platelet rich plasma. Clin Plast Surg 2016;43(3):473–88.
Klinger M, Klinger F, Caviggioli F, Maione L, Catania B, Veronesi A, et al. Fat Grafting for Treatment of Facial Scars. Clin Plast Surg 2020;47(1):131–8.
Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg 2013;132(4):1017–26.
Gal S, Ramirez JI, Maguina P. Autologous fat grafting does not improve burn scar appearance: a prospective, randomized, doubleblinded, placebo-¬controlled, pilot study. Burns 2017;43(3):486–89.
Jan SN, Bashir MM, Khan FA, Hidayat Z, Ansari HH, Sohail M, et al. Unfiltered Nanofat Injections Rejuvenate Post burn Scars of Face. Ann Plast Surg 2019;82(1):28–33.
Lee JW, Park SH, Lee SJ, Kim SH, Suh IS, Jeong HS, et al. Clinical Impact of Highly Condensed Stromal Vascular Fraction Injection in Surgical Management of Depressed and Contracted Scars. Aesthetic Plast Surg 2018;42(6):1689–98.
Jaspers MEH, Brouwer KM, van Trier AJM, Groot ML, Middelkoop E, van Zuijlen PPM. Effectiveness of autologous fat grafting in adherent scars: results obtained by a comprehensive scar evaluation protocol. Plast Reconstr Surg 2017;139(1):212–9.
Pallua N, Kim BS. Micro fat and Lipo concentrate for the Treatment of Facial Scars. Clin Plast Surg 2020;47(1):139–45.
Bollero D, Pozza S, Gangemi EN, De Marchi A, Ganem J, AM El K, et al. Contrast-enhanced Ultrasonography evaluation after autologous fat grafting in scar revision. G Chir 2014;35(11-12):266–73.
Riyat H, Touil LL, Briggs M, Shokrollahi K. Autologous fat grafting for scars, healing and pain: a review. Scars Burn Heal 2017;3:2059513117728200.
Gu Z, Li Y, Li H. Use of Condensed Nanofat Combined with Fat Grafts to Treat Atrophic Scars. JAMA Facial Plast Surg 2018;20(2):128–35.
Jan SN, Bashir MM, Khan FA, Hidayat Z, Ansari HH, Sohail M, et al. Unfiltered Nanofat Injections Rejuvenate Post burn Scars of Face. Ann Plast Surg 2019;82(1):28–33.
Kim JH, Jung M, Kim HS, Kim YM, Choi EH. Adipose-derived stem cells as a new therapeutic modality for ageing skin. Exp Dermatol 2011;20(5):383–7.
Klinger M, Marazzi M, Vigo D, Torre M. Fat injection for cases of severe burn outcomes: a new perspective of scar remodeling and reduction. Aesthetic Plast Surg 2008;32(3):465–9.
Brongo S, Nicoletti GF, La Padula S, Mele CM, D'Andrea F. Use of lipofilling for the treatment of severe burn outcomes. Plast Reconstr Surg 2012;130(2):374e–6.
Deng C, Yao Y, Liu Z, Li H, Yang Z, Wang D, et al. Chronic wound treatment with high-density nano fat grafting combined with negative pressure wound therapy. Int J Clin Exp Med 2019;12(2):1402–11.
Brown JC, Shang H, Yang N, Pierson J, Ratliff CR, Prince N, et al. Autologous Fat Transfer for Scar Prevention and Remodeling: A Randomized, Blinded, Placebocontrolled Trial. Plast Reconstr Surg Glob Open 2020;8(5):e2830.
Tsuji W, Rubin JP, Marra KG. Adipose-¬derived stem cells: implications in tissue regeneration. World J Stem Cells 2014;6(3):312–21.
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