• Khwaja Tahir Aziz Pediatrics
  • Naheem Ahmed
  • Abdul Ghaffar Nagi


Background: Febrile fits is common problem in children. Among other risk factors, iron deficiency anemia is considered as aggravating factor for febrile fits. Iron deficiency anemia is preventable and treatable disease. Aims & Objectives: To find out iron deficiency anemia as risk factor for febrile fits. Materials & Methods: It was retrospective, case control study. 30 cases of febrile fits were recorded. Control group of 30 cases was taken at the same time with same variables but without febrile fits. Their temperatures and weights were recorded and laboratory hematological parameters Hemoglobin, Hematocrit, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Blood Count (RBC) and Red Cell Distribution Width values were collected and analyzed statistically with SPSS Ver 20.0 Results: Mean Hemoglobin, Hematocrit, RBC, MCV, MCH, MCHC and RDW had significant P value (P value <0.05) in case group as compared to control group. Conclusion: As Iron Deficiency Anemia is a risk factor for febrile fits, treatment and prevention of iron deficiency anemia can decrease incidence of febrile fits.IRON DEFICIENCY ANAEMIA AS RISK FACTOR FOR SIMPLE FEBRILE SEIZURES: A CASE CONTROL STUDY

Author Biography

Khwaja Tahir Aziz, Pediatrics

HOD/Consultant Pediatrician/Assistant ProfessorShaikh Khalifa Bin Zayed Al-Nahyan Hospital/AJK Medical College Muzaffarabad


Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, et al: Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 2010;51(4):676–85.

Mohamad A. Mikati and Abeer J. Hani. Febrile Seizures, In: Kliegman R, Nelson WE, editors. Nelson Text Book of Pediatrics, 20th Edition, Publisher Elsevier, Philadelphia; 2015. p.2829–31.

Shinnar S. Febrile seizures. In: Swaiman KF, Ashwal S, Ferriero DM, editors. Pediatric Neurology: Principles & Practice. 4th ed. Philadelphia: Mosby Elsevier; 2006. p.1079–89.

Epstein LG, Shinnar S, Hesdorffer DC, Nordli DR, Hamidullah A, Benn EK, et al. Human herpesvirus 6 and 7 in febrile status epilepticus: The FEBSTAT study. Epilepsia 2012;53(9):1481–8.

Huang CC, Wang ST, Chang YC, Huang MC, Chi YC, Tsai JJ. Risk factors for a first febrile convulsion in children: a population study in southern Taiwan. Epilepsia 1999;40(6):719–25.

Landreau-Mascaro A, Barret B, Mayaux MJ, Tardieu M, Blanche S. Risk of early febrile seizure with perinatal exposure to nucleoside analogues. Lancet 2002;359(9306):583–4.

Berg AT, Shinnar S, Shapiro ED, Salomon ME, Crain EF, Hauser WA. Risk factors for a first febrile seizure: a matched case-control study. Epilepsia 1995;36(4):334–41.

Graves RC, Oehler K, Tingle LE. Febrile seizures: risks, evaluation, and prognosis. Am Fam Physician 2012;85(2):149–53.

Pisacane A, Sansone R, Impaglizzo N, Coppola A, Ronaldo P, D’Apuzzo A, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. BMJ 1996;313(7056):343.

Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C, et al. The association between iron deficiency and febrile seizures in childhood. ClinPediatr (Phila) 2009;48(4):420–6.

Florentino RF, Guirric RM. Prevalence of nutritional anaemia in infancy and childhood with emphasis on developing countries. In: Stekel A, editors. Iron nutrition in infancy and childhood. New York: Raven Press; 1984. p.61–74.

Stoltzfus R. Defining iron-deficiency anaemia in public health terms: a time for reflection. J Nutr 2001;131(2Suppl-2):S565–7.

WHO. Iron deficiency anaemia. Assessment Prevention Control. A Guide for Program Managers. Geneva: WHO/NHD/013; 2001.

Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting Neural and Behavioral Effects of Iron Deficiency in Infancy. Nutr Rev 2006;64(5 Pt 2):34–43.

Parks YA, Wharton BA. Iron Deficiency and the Brain. Acta Paediatr Scand, Suppl 1989;361:71–7.

Beard JL. Iron deficiency alters brain development and functioning. J Nutr 2003;133(5 Suppl 1):S1468–72.

Batra J, Seth PK. Effect of iron deficiency on developing rat brain. Indian J Clin Biochem 2002;17(2):108–14.

de Deungria M, Rao R, Wobken JD, Luciana M, Nelson CA, Georgieff MK. Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selected regions of neonatal rat brain. Pediatric Res 2000;48(2):169–76.

Daoud AS, Batieha A, Abu-Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia 2002;43(7):740–3.

Sultan A, Fayaz M, Khan AN, Fayaz A. Relationship of Anaemia with Simple Febrile Convulsions. J Ayub Med Coll Abbottabad 2013;25(1-2):156–8.

Ali MA, Maqsood SU, Qureshi MT. Association of iron status with febrile seizures. Khyber Med Univ J 2012;4(4):170–3.

Ashfaq M, Channa Y, Nisa BU. Frequency of Iron Deficiency Anaemia in Febrile Seizures in Children and Comparison with Febrile Children without Seizures. Pak Pediatr J 2014;38(2):113–7.

Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenebein M. Does iron deficiency raise the seizure threshold? J Child Neurol 1995;10(2):105–9.

Momen AA, Hakim ZM. Case control study of relationship between anaemia and febrile convulsion in children between 9 months to 5 years of age. Jundishapur Sci Med J 2003;35(3):50–4.

Fallah R, Trinandazi B, Ferdoian F, Fadavi N. Iron deficiency and iron deficiency anaemia in children with first attack of seizures and in healthy control group; a comparative study. Iran J Child Neurol 2014;8(3):18–23.

Ahmed BA. Iron Deficiency as a Risk Factor for Simple Febrile Seizures. Med J Cairo Univ 2013;81(2):51–4.

Srinivasa S, Reddy SP. Iron defeiciency anaemia in children with simple febrile seizures-A cohort study. Curr Pediatr 2014;18(2):95–8.

Raju MS, Kumar MP. Study of Association between Iron Deficiency Anaemia and Febrile Seizures. J Evol Med Dent Sci 2015;4(39):6818–23.

Omran MS, Tamaddoni A, Nasehi MM, Babazadeh H, Navaei RA. Iron Status In Febrile Seizure: A Case-Control Study. Iran J Child Neurol 2009;l 4(4):39–42.

Idro R, Gwer S, Williams TN, Otieno T, Uyoga S, Fegan G, et al. Iron deficiency and acute sizures: results from children living in rural Kenya anda meta-analysis. PLoS One 2010;5(11):e14001.