GESTATIONAL TROPHOBLASTIC DISEASE

Authors

  • Nousheen Aziz
  • Sajida Yousfani
  • Irfanullah Soomro
  • Firdous Mumtaz

Abstract

Background: Molar pregnancy represents a significant burden of disease on the spectrum ofGestational Trophoblastic Disease (GTD). The incidence appears to be quite high in South Asia. Theobjective of this study was to determine the frequency of GTD, and clinical presentation, managementand outcome of patients with molar pregnancy. Methods: This retrospective, descriptive study wasconducted at Nuclear Institute of Medicine and Radiotherapy (NIMRA), Jamshoro from 1st Jan to 31stDec 2009. All patients diagnosed and registered as GTD were included in the study. The clinicalrecords of all molar patients were reviewed regarding presentation, treatment, and follow-up. Results:There were a total of 167 patients presenting with different female genital tract neoplasia at NIMRAduring the study period, including 39 (29.35%) cases of GTD. Hydatidiform mole was seen in 33(84.61%) patients. Complete mole in 31 (79.48%), partial mole in 2 (5.12%) patients, invasive mole in1 (2.56%) patient, and choriocarcinoma in 5 (12.82%) patients. The mean age of the patients was27±9.8 years. The highest incidence was found in nulliparous and para 1. Thirty-two patients hadsuction evacuation and 1 patient underwent hysterectomy. Patients received chemotherapy, 17(54.54%) patients followed protocol for 3–6 months. Conclusion: Frequency of molar pregnancy washigh, more common in low-parous, poor socioeconomic class women, and usually presented late.Keywords: Gestational trophoblastic disease, Hydatidiform mole, management, outcome, women

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Published

2012-03-01