LIVER FUNCTION TESTS IN PREECLAMPSIA
AbstractBackground: Preeclampsia is a multisystem disorder that can induce damage to cardiovascular system,kidneys, brain and liver. Pregnancy-induced hypertension (PIH) is responsible for significant maternaland perinatal morbidity. This study was conducted to compare the liver function tests in preeclampsiawith normal pregnancy. Methods: This study was carried out on 100 pregnant women after 20 weeks ofgestation admitted in Obs/Gyn units of Ayub Teaching Hospital, Abbottabad. The subjects were dividedinto two groups. Group A consisted of 50 cases of preeclampsia having blood pressure 140/90 mmHg,proteinuria in 24 hours 300 mg and oedema; Group B had 50 normal pregnant women after 20 weeksof gestation. The data including BMI, parity, period of gestation, blood pressure and presentingcomplaints of all subjects were recorded. Serum bilirubin and plasma levels of liver enzymes ALT, ASTand ALK were measured. Results: The mean BMI of the cases was 29.04±3.97 and that of controls was26.54±3.11. The mean value of serum bilirubin in cases was 10.78±3.74 µmol/L and in controls it was7.92±2.42 µmol/L (p<0.001). The mean values of enzyme ALT in cases was 55.81±31.93 U/L while inthe controls it was 15.22±3.30 U/L (p<0.001). Mean serum AST in the cases was 41.34±10.76 U/L andin the controls it was 24±2.54 U/L (p<0.001). Mean ALK level of cases before delivery was454.16±243.69 U/L, and in controls it was 181.34±66.76 U/L (p<0.001). Conclusion: Raised levels ofserum bilirubin and liver enzymes ALT, AST and ALK were found in preeclampsia cases.Keyword: Preeclampsia, Liver Function Tests, Pregnancy, Hypertension, Morbidity, Women
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