NEUTROPHIL FUNCTION (INNATE IMMUNITY) DURING RAMADAN

Authors

  • Afshineh Latifynia
  • Mohammad Vojgani
  • Mohammad Javad Gharagozlou
  • R Sharifian

Abstract

Background: Fasting during the month of Ramadan is one of the essential religious practices ofMuslims. The aim of this study was to evaluate opsonisation, phagocytosis, and nitrobluetetrazolium (NBT) reduction by white blood cells in normal, healthy, male subjects under nonfasting (before Ramadan) and fasting (after Ramadan) conditions. Methods: In this study, 13Muslim men, aged 28-54 years, whose health was confirmed by health application forms, gaveblood samples one week before the beginning of the holy month of Ramadan and during the lastweek of Ramadan. Blood samples were tested for neutrophil phagocytosis, serum opsonisationpower, and NBT reduction. Results: Despite a decline in the neutrophil phagocytic index andserum opsonisation index, the percentage of neutrophils participating in phagocytosis increasedwith fasting. In addition, there was an increase in the percentage of neutrophils demonstratingNBT reduction. Although there was a decrease in opsonisation of the serum, the increasedpercentage of opsonisation compensated for this defect. Conclusion: This study demonstrates thebeneficial effect of fasting during Ramadan on neutrophil phagocytic function.Keywords: Neutrophil, Ramadan, Nitroblue tetrazolium, Phagocytosis, Opsonisation

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Published

2009-12-01