NEONATAL OUTCOME IN PRE-ECLAMPTIC PATIENTS

Authors

  • Attiya Ayaz
  • Taj Muhammad
  • Shaheryar A Hussain
  • Sadia Habib

Abstract

Background: Pre-eclampsia (PE) is defined as hypertension (blood pressure of 140/90 mm Hg ontwo occasion 4–6 hour apart or single reading of diastolic blood pressure of >110 mm Hg) andproteinuria developing after 20 weeks of pregnancy up to 6 weeks post partum in previouslynormotensive, non-proteinuric women. The aim of this study was to determine the neonatal outcomein babies born of pre-eclamptic patients. Methods: It is a cross-sectional comparative study and wascarried out in department of Obstetrics and Gynaecology unit C of Ayub Teaching Hospital,Abbottabad from 1st January 2007 to 30th June 2007. The study population included all casespresenting with pre-eclampsia after 20 weeks gestation to emergency and OPD and controls (Normalsubject without pre-eclampsia). Results: A total of 73 cases of pre-eclampsia were recorded in studyperiod and were matched for age, gestational age and parity with controls. Neonatal outcome datashowed a perinatal mortality of 328 neonates per 1000 total births, major cause being still births andintrauterine death (IUD). Decreased APGAR score was present in 31 cases and 3 controls.Conclusion: Pre-eclampsia has great implication on adverse neonatal outcome. The variouscomplications seen are low APGAR score, IUD, low birth weight, intrauterine growth restriction andincreased need for admission to Neonatal Intensive Care Unit (NICU).Keywords: Pre-eclampsia, Perinatal mortality, Eclampsia, IUGR, Still Birth, NICU, APGAR score

References

Duckitt K, Harrington D. Risk factors for pre eclampsia

antenatal booking: systemic review of controlled studies BMJ

;330:565–7.

Al-Mulhim AA, Abu-Heija A, Al-Jamma F, El-Harith el-HA.

Pre-eclampsia: maternal risk factors and perinatal outcome.

Fetal Diagn Ther 2003;18:275–80.

North RA, Taylor RS, Schellenberg JC. Evaluation of a

definition of pre eclampsia. Br J Obstet Gynaecol

;106:767–73.

Brown Ma, Hague WM, Higgins J, Lowe S, McCowan L,

Oats J, et al. The detection, investigation and management of

hypertension in pregnancy: full consensus statement. Aust

NZ J Obstet Gynaecol 2000;40:139–55.

Hnat MD, Sibai BM, Caritis S, Hauth J, Lindheimer MD,

Macpherson C, et al. perinatal outcome in women with

recurrent pre eclampsia compared with women who develop

pre eclampsia as nulliparas. Am J Obstet Gynecol

;186:422–6.

Chesley Lc: Diagnosis of pre-eclampsia. Obstet Gynecol

;65:423–5.

Ara J, Jamal M, Sultana N. Perinatal outcome in pregnancy

induced hypertensive mothers. Pak Armed Forces Med J

;54(8):76–8.

Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA,

McLaughlin MK. Pre-eclampsia: an endothelial cell disorder.

Am J Obstet Gynecol 1989;161:1200–4.

Campbell DM, Mac Gillivary I, Carr-Hill R. Pre-eclampsia in

second pregnancy. Br J Obstet Gynaecol 1985;92:131–40.

Davey DA & MacGillivray I. The classification and

definition of hypertensive disorder of pregnancy. Am J

Obstet Gynecol 1988;158:892–8.

Walsh SW. What causes endothelial cell activation in

preeclamptic women? Am J Pathol 2006;169:1104–6.

Published

2009-06-01