SCHWANN CELLS: LEADER OF NERVENKITT

Authors

  • Muhammad Mirajullah
  • Shen Xinya

Abstract

Schwann cells (SC) are the major & only glial cell element of peripheral nervous system (PNS) which by virtue of their unique biological activities give the distinction of regeneration not only to the peripheral nervous system (PNS) but also induce regeneration in the central nervous system (CNS) by changing the hostile & inhospitable environments around its neurons to neurite promoting favourable conditions. These multifunctional cells synthesize, secrete & express many neurotrophic, neurotropic, neurite promoting & growth factors, major myelin glycoproteins, cell adhesive molecules (CAMs), basement membrane components as well as a cornucopia of receptors at various stages of life. Their important role in neural tissue development, organization & maintenance cannot overshadow their emerging vital contributions to the ongoing studies on demyelinating diseases (e.g. multiple sclerosis) & other debilitating and disfiguring neurological defects  (e.g. neurofibromatosis). Underlying SC defects may be responsible for abnormalities in peripheral neuropathies. SC are the primary cells in the disfiguring disease of neurofibromatosis as well as shoulder the responsibility for Schwannoma & Neurilemoma tumours. Their versatility is evidenced by their phagocytic nature during Wallerian & traumatic degeneration. They are indispensable to the normal functioning of axons. Inhibiting their proliferation at the stage of regeneration not only retards axonal growth but profoundly impairs myelination. Their proliferation & physical presence is a prerequisite for the reparative process providing a proper terrain or scaffolding essential for the regeneration & survival of neurons.

References

Schwann T. Mikroskopische untersuchungen uber die uebereinstimmung in der struktur und dem wachstum der tiere und pflanzen. Sander. Berlin, 1839.

Lim R and Bosch P. Isolation of astrocytes and Schwann cells for culture. In: Cell Culture (Coon PM Ed.), Academic Press CA.;1990:47-55.

Murray MR & Stout AP. Characteristics of human Schwann cells in vitro. Anat Rec,1940;84:293-95.

Martini R. Expression and functional roles of N-CAMs and Extracellular Matrix components during development and regeneration of peripheral nerves. J Neurocyt, 1994;23:1-28.

LeBeau JM, Ellisman MH, & Powell HC. Ultrastructural and morphometric analysis of long-term peripheral nerve regeneration through silicone tubes. J Neurocyt, 1988;17:161-72.

Anderson PN, Nadim W, & Turmaine M. Schwann Cells migration through freeze killed peripheral nerve grafts without accompanying axons. Acta Neuropathol, 1991;82:193-9.

Keynes RJ. Schwann Cells during neural development and regeneration: Leaders or followers? TINS, 1987;10:137-9.

Bailey SB, Eichler ME, Villadiego A, & Rich KM. The influence of Fibronectin & Laminin during Schwann Cells migration and peripheral nerve regeneration through silicon chambers. J Neurocyt, 1993;22:176-84.

Bunge MB, Bunge RP, Kleitman N, & Dean AC. Role of peripheral nerve extracellular matrix in Schwann Cell function and in neurite regeneration. Dev Neurosci, 1989;11:348-60.

Berry M, Rees L, Hall S, Yiu P, & Sievers J. Optic axons regeneration into Sciatic Nerve isografts only in the presence of Schwann Cells. Brain Res Bull, 1988;20(2):223-31.

Smith GV, & Stevenson JA. Peripheral nerve grafts lacking viable Schwann Cells fail to support CNS axonal regeneration. Exp Brain Res, 1986;69:299-306.

Gulati AK. Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve. J Neurosurg, 1988;68:117-23.

Carpenter MK et al. CNS white matter can be altered to support neuronal outgrowth. J Neurosci Res, 1994;37:1-14.

Gue'nard V, Aebischer P, & Bunge RP. The astrocytes inhibition of peripheral nerve regeneration is reversed by Schwann Cells. Exp Neurol, 1994;126:44-60.

Maffei L et al. Schwann Cells promote the survival of rat ganglion cells after Optic Nerve section. PNAS, USA, 1990;87:1855-9.

Schwab ME, & Caroni P. Oligodendrocytes & CNS myelin are non-permissive substrates for neurite growth & Fibroblast spreading in vitro. J Neurocyt,1988;8:2381-93.

Paino CL, & Bunge MB. Induction of axon growth into Schwann Cell implants grafted in to lesioned adult rat spinal cord. Exp Neurol, 1991;114:254-7.

Tohyama K, & Ide C. The localization of Laminins and Fibronectin on the Schwann Cell Basal Lamina. Archs Histol Jpn, 1986;49:519-32.

Thoenen H. The changing scene of Neurotrophic Factors. TINS, 1991;14:165-70.

Bähr M, Eschweiler GW, & Wolburg H. Precrushed Sciatic Nerve grafts enhance the survival and axonal regrowth of Retinal Ganglion Cells in adult rats. Exp Neurol, 1992;116:13-22.

Fawcett JW, & Keynes RJ. Peripheral nerve regeneration. Annu Rev Neurosci, 1990;13:43-60.

Kuecherer-Ehret A, et al. Immunoelectron microscopic localization of Laminin in normal and regenerating mouse Sciatic Nerve. J Neurocyt, 1990;19:101-9.

Wang G-Y. Behavior of axons, SC, & perineurial cells in nerve regeneration with in transplanted nerve grafts: Effects of anti-Laminin & anti-Fibronectin antisera. Brain Res, 1992;583:216-26.

Tedeschi B, & Liuzzi FJ. Axotomized frog Sciatic Nerve releases diffusible Neurite Promoting Factors. Dev Brain Res, 1992;97:107-23.

Ide C. Nerve regeneration and Schwann Cell Basal Lamina: Observations of the long term regeneration. Arch Histol Jpn, 1983;46:243-51.

Reichert F, Saada A, & Rotshenker S. Peripheral nerve injury induces Schwann Cells to express two macrophage phenotypes: Phagocytosis and the galactose-specific lectin MAC-2. J Neurosci, 1994;14(5):3231-45.

Notter MFD et al. Primate Schwann Cells express multiple growth factors in vitro. Soc Neurosci Abstr, 1991;17:1502.

Neuberger TJ & DeVries GH. Distribution of Fibroblast Growth Factor in cultured Dorsal Root Ganglia neurons and Schwann Cells. I. Localization during maturation in vitro. J Neurocyt, 1993;22:436-48.

Neuberger TJ, & DeVries GH. Distribution of Fibroblast Growth Factor in cultured Dorsal Root Ganglia neurons & Schwann Cells. II. Redistribution after neural injury. J Neurocyt, 1993;22(6):449-60.

Hardy M, Reddy UR, & Pleasure D. PDGF and regulation of Schwann Cell proliferation in vivo. J Neurosci Res, 1992;31:254-62.

Taniuchi M, Clark HB, & Johnson(Jr) EM. Induction of Nerve Growth Factor in Schwann Cells after axotomy. PNAS, USA, 1986;83:4094-8.

Jung-Testas I, Schumacher M, Bugnard H, & Baulieu EF. Stimulation of rat Schwann Cell proliferation by estradiol: Synergism between the estrogen and cAMP. Dev Brain Res, 1993;72:282-90.

Ignatius MJ et al. Expression of apolipoprotein E during nerve degeneration and regeneration. PNAS USA, 1986;83:1125-9.

Bolin LM, & Shooter EM. Characterization of a Schwann Cell neurite promoting activity that directs motoneuron axon outgrowth. J Neurosci Res, 1994;37(1):23-35.

LeBeau JM et al. Extracellular fluid conditioned during peripheral nerve regeneration stimulates Schwann Cell adhesion, migration, & proliferation. Brain Res, 1988;459:93-104.

Plantinga LC et al. The expression of B-50 / GAP-43 in Schwann Cells is upregulated in degenerating distal nerve. Soc Neurosci Abstr, 1992;18:432.

Krasnoselsky A et al. H Growth Factor is a mitogen for Schwann Cells and is present in NF. J Neurosci, 1994;14(12):7284-91.

Pareek S et al. Detection and regulation of PMP-22mRNA and protein in cultured Schwann Cells. Soc Neurosci Abstr, 1992;18:1490

Scherer SS et al. Axons regulate Schwann Cells expression of the POU transcription factor SCIP. J Neurosci, 1994;14(4):1930-42.

Shy ME et al. Axonal regulation of C-jun expression in Schwann Cells in vivo. Soc Neurosci Abstr, 1992;18:1089.

Vaudano E et al. Expression of C-jun protein in Schwann Cells depends on their environment. Soc Neurosci Abstr, 1992;18:765.

Constable AL et al. Production of prostanoids by Lewis rat Schwann Cells in vitro. Brain Res, 1994;635:75-80.

Ryan JJ et al. Role for the SCF/KIT complex in Schwann Cells neoplasia and mast cell proliferation associated with neurofibromatosis. J Neurosci Res, 1994;37:415-32.

Porter S, Glaser L, and Bunge RP. Release of autocrine growth factor by primary and immortalized Schwann Cells. PNAS, USA, 1987;84:7768-72.

Eldridge CF, & Bunge RP. Normal Schwann Cells release a factor which stimulates normal Schwann Cell proliferation. Anat Rec, 1987;218:40a.

Muir D, and Varon S. Activation of stromyelsin is required for autocrine inhibition of Schwann Cell proliferation. Soc Neurosci Abstr, 1991;17:932.

Eccleston PA, Jessen KR, & Mirsky R. Spontaneous immortalization of Schwann Cells in culture: short-term cultured Schwann Cells secrete growth inhibitory activity. Development, 1991;112:33-42.

Gu Li Qiang, and Zhu Jia Kai. Experimental study of the Schwann Cell derived Neurotrophic Factors. Chinese J Microsurg, 1993;16(2):125-8.

Fine A. Transplantation in the CNS. In " The Biology of Brain: From Neuron to Network (Llna's RR ed.), WH Freeman & Company, NY, 1988;149-160.

Mirajullah M. Studies on Schwann Cells cultures: the potential role in peripheral nerve regeneration along with Laminin in SD albino rats. Ph.D (Neuroanatomy) thesis. Shanghai Medical University, 1995