ROLE OF PARACETAMOL AGAINST THE EROSIVE ACTION OF RECTIFIED SPRIT ON STOMACH IN ALBINO RATS
AbstractABSTRACTThe protective role of paracetamol against rectified spirit (nonspecific injuringagent) on the gastric mucosa of albino rat was observed under dissecting as well aslaboratory micro-scope. A dose of250 mg/kg body weight provided complete protectionunder dissecting micro-scope. However, gum acacia with rectified spirit treatmentprovided significant decrease in the erosion score. Under laboratory microscope asignificant increase in the thickness of the mucosa was observed in combined treatmentof paracetamol with rectified spirit as compared to rectified spirit alone or gum acaciawith rectified spirit. A slight exfoliation and flattening of the surface epithelium mayprobably be due to increase in the secretory activity of chief cells. A significant increasein the secretory activity of the mucous neck cells in the group treated with rectified spiritplus paracetamol may be attributed to the increased bio-synthesis of prostaglandin fromthe mucous neck cell, which provides partial protective role against ulcerogenic agent.
Bonta, L.L A study of the effect of some gluco oorticoids and ACTH on the articically induced gastic
ulcers of the rat, Arch, Int. Pharamacodyn, 132: 147-163.
Bum, J.H. Lecture notes on pharmacology 6th edition, Oxford, Balckwell Publication, 1961.
Konturck, S.J.. Brzozowski, T., Plastuchi, I, and Tradecki, Prevnedon of ethanol and aspirin induced
gastic mucosal lesions by paracetamol and salicyclate in rats: Rate of endogenous prostaglandin
Gut., 1982,83, 536-540.
Peter, B.H. Frain, C. J and Morel, B E. (1983) comparison of 650 mg aspirin and 1000 mg
aectaminophren with each other and with placebo in moderately severe headache. Am J. Med., 74
Prescott, L.F. (1976) Anti-inflammatory and analgesics and drugs used in the treatment of
Rheumatoid arthritis and Gout. In Meylefs side effect of drugs (M.N.G. Dukes, ed) Excerpta Medica
Amsterdam pp 207-240.
Robert, A., James, E.N., Cleo, L., Alexandor, J.H. Cytoprotection by prostaglandin in rats.
Gastroenteralogy, 1979. 77:433-443.
Seegers, A.J.M., Jager, L.P., Noord Wijk, T. V. Effect of phenacctin, paracetamol and acetyle
salicylic acid in the rat stomach. Dose response relationship time course of erosion development
and effect of on acid secretion. J. Pharm, Parmacol, 1979. 31:840 -848.
Stem, A-l, Hogan, D.L., Khon, L.H. and Isenbergh, J.I., Protective effect of acetaminophen against
aspirin and ethanol induced damage to human gastic mucosa. Gastroenterology, 1984; 86:728-733.
Terano, A. Ivey, K.J., Stachura, J., Mclcenzie, W.N. Krause, W.J. Herojinia, H. Wyche, J.H. and
Sekhon, S. Cell culture of rate gastic mucosa Gastroenterology. 1982; 82:1195(abstract).
Van Kolfschoten, A.A., Zandberg, V.P., Jaggar, I.P., Noordvvijk, J.V. Protection by Paracetamol
against various gastic irritants in the rat. Toxicol. Appl. Pharmacol, 1983,69:73 – 42.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.