ROLE OF PARACETAMOL AGAINST THE EROSIVE ACTION OF RECTIFIED SPRIT ON STOMACH IN ALBINO RATS
AbstractABSTRACTThe protective role of paracetamol against rectified spirit (nonspecific injuringagent) on the gastric mucosa of albino rat was observed under dissecting as well aslaboratory micro-scope. A dose of250 mg/kg body weight provided complete protectionunder dissecting micro-scope. However, gum acacia with rectified spirit treatmentprovided significant decrease in the erosion score. Under laboratory microscope asignificant increase in the thickness of the mucosa was observed in combined treatmentof paracetamol with rectified spirit as compared to rectified spirit alone or gum acaciawith rectified spirit. A slight exfoliation and flattening of the surface epithelium mayprobably be due to increase in the secretory activity of chief cells. A significant increasein the secretory activity of the mucous neck cells in the group treated with rectified spiritplus paracetamol may be attributed to the increased bio-synthesis of prostaglandin fromthe mucous neck cell, which provides partial protective role against ulcerogenic agent.
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