• Umar Draz
  • M. Zahoor Janjua


ABSTRACT:The ulcerogenic effect of fenopron and its protection by paracetamol was observed underdissecting as well as laboratory microscope. The protection was complete under dissectingmicroscope, in the dose of 250 mg/kg. body weight but there was significant decrease in erosionscore with gum acacia followed by Fenopron.Mucosal thickness was significantly increased in paracetamol followed by fenopron group ascompared to other group. Increased secretory activity of mucous neck cells was observed in thesame group which might have resulted as protection of rat stomach by the damaging effect offenopron; due to increased production of mucous as well as prostaglandin.


Rains, A.J.H. and Richie, H.W., Bailay and Love a short practice of surgery; 19the ed. London English Language

Book Society, 1985, pp 789.

Ivey, K.J., Gastro-intentional effect of anti-pyritic analgesics. Am. J. Med. 1983; 14: 53-64.

Seegers, A.J.M., Jager, L.R and Noordwijk, T.V. Effect of Phenacetin, paracetamol and caffeine on erosive

activity of acetylesali cylic acid in the rat stomach. Dose response relationship, time course of erosion

development and effect on acid secretion. J. Pharm. Phannacal, 1979; 31: 840-48.

Reynold, J.E.E, Martindale. The extra pharmacopoeia. 28the ed. London Pharmaceutical Press, 1982; pp

, 265.

Staskar, R.S., and Bhandarkar, S.D., Pharmacology and Pharmacotherapeutics. 8the ed. Bombay popular

drakashan, 1983; pp 148.

Diamantis, W., Melton, J., Sofia, R.D., Ciofalo, V.B., Comparative gastric ulcerogenic effect of mesecla- zone,

chlorosalicylic acid and other nonsteroidal anti-inflammatory' drags following acute repeated oral

administration to rat. toxical Appl. Pharmacal, 1980; 52: 554-61.

Bonta, L.I. A Study of the effect of some glucocorticoid and ACTH on artificially induced gastric ulcer of the rat.

ARCH. Int. Pharmacodym, 1961; 132; 147-63.

Konturek, S.J., Brozozowski, T., Plastucki, I., and trade chi. Prevention of ethanol and aspirin induced gastric

mucosal lesion by paracetamol and salicylate in rats. Role of endogenous prostaglandin. Gut. 1982; 23 :536-40.

Van Kolfschoten, T.A., Zandberg, V.P., Jagger, I.P., Noordwijk, J.V. Protection by paracetamol against various

gastric irritant in the rat. Toxical. Appl. Pharmacol, 1983; 69: 37 12.

terano, A., Ivey, K.J., Stachura., Mechanize, W.N., Krause, W.J., Hosojima, 11., Wyeha, J.H. and Sekhon, S. Cell

culture of rat gastric mucosa. Gasterocnlerology 1982; 82: 1195 (abstract).

Stem, A.I., Hagan, D.L., Kohn, L.H., and Isenberg, J.I., Protection of acetaminophen against aspirin and ethanol

induced damage to human gastric mucosa. Gastroenterology, 1981; 86: 728-38

Robert, A., James, E.N., Cleo, L. and Alexander, J.H. Cytoprotection by prostaglandin in rats. Gastroenterology,

; 77: 133-13.