GASTRIC ULCEROGENICITY OF FENOPRON ANTAGONIZED BY PARACETAMOL IN ALBINO RATS
AbstractABSTRACT:The ulcerogenic effect of fenopron and its protection by paracetamol was observed underdissecting as well as laboratory microscope. The protection was complete under dissectingmicroscope, in the dose of 250 mg/kg. body weight but there was significant decrease in erosionscore with gum acacia followed by Fenopron.Mucosal thickness was significantly increased in paracetamol followed by fenopron group ascompared to other group. Increased secretory activity of mucous neck cells was observed in thesame group which might have resulted as protection of rat stomach by the damaging effect offenopron; due to increased production of mucous as well as prostaglandin.
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