• Salma Aslam Kundi
  • Mary Forsling
  • Haluk Kelemistur


Ovariectomy of the mature female rat results in a fall in the plasma vasopressin concentrationalthough the ovarian content of the hormone is low. To investigate this further, functional ovariectomy wasdone in the rats by administration of an antioestrogen acting drug (Tamoxifen).Studies performed on female rats indicated significant reductions in uterine weight and plasmavasopressin levels.The uterine weights decreased from 206.9 mg 1100 gm body weight in control group to 142.2 mg/100 gm body weight in experimental group.Plasma vasopressin levels decreased from 1.15 microunits /ml in the control group to 0.38microunits /ml in the experimental group.The study confirms that like surgically ovariectomized rats, Junctional ovariectomy also causesdecreases in uterine weights and plasma vasopressin levels.


Al Sendi A, Forsling ML, Khan M & Peysner K. Fluid

balance in cycling rats and ovariectomized rats treated with

oestradiol benzoate. Journal of Physiology, 1985, 371: 189

Dignam WS, Voskain J & Assali NS. Effects of oestrogens

on renal hemodynamics and excretion of electrolytes in

human subjects. Journal of Clinical Endocrinology &

Metabolism, 1956, 16: 1032 - 1041

Butcher RL, Collins WE & Fugo NW. Plasma

concentrations of LH, FSH, prolactin, progesterone &

oestradiol-17B throughout the 4-days oestrous cycle of the

rat. Endocrinology, 1974, 94: 1704- 1707

De Vries GJL, Buijs RM & Sluiter AA. Gonadal hormone

action on the morphology of the vasopressinergic

innervation of the adult rat brain. Brain Research, 1984, 298:


Forsling JML, Akerlund M & Stromberg P. Variation in

plasma concentrations of vasopressin during the menstrual

cycle. Journal of Endocrinology, 1981, 89: 263-266

Windle R, Samuels L, Williams E & Forsling ML. Journal

of Endocrinology, 1988, 119 (suppl): 37

Guzick J, Wang DY & Bulbrook RD. The prevention of

breast cancer. Lancet, 1986, i: 83-86.

Wakeling AE & Slater SR. Cancer Treatment Reports,

June/July 1980, Vol 64, No. 67.

Wade GN, Blaustein JD, Gray JM & Meredith JM.

ICI182780, a pure anti-oestrogen that affects behaviour and

energy balance in rats without acting in brain. American

Journal of Physiology, Dec 1993, 265 (6 pt 2) R.: 1392-8.

Batanagar AS, Batzl C, Hausler A & Nogues V. The role of

oestrogen in the feedback regulation of follicle-stimulating

hormone secretion in the female rat. Journal Steroid

Biochem Mol Biol, Dec 1993, 47 (1-6): 161-6.

Morozova DV. Effect of oestrogen on uterus of mice of

different strains. Biull Eksp -Biol -Med, Dec 1991, 112 (12):


Skowsky WR. Effect of sex steroid hormones on vasopressin

in intact and castrated male and female rat. Endocrinology,

, 104: 105-108.

Khan MA, Khan MUA, Aslam M & Babar MK. Fluid

balance in cycling and ovariectomized rats treated with

oestradiol benzoate. Pak Armed Forces Medical Journal,

, 44 (1): 7-14.

Khan MA, Khan MUA & Aslam M. Food intake and water

retention over the oestrous cycle of the rat treated with

difluoro- methylomithine (DFMO). Pak Armed Forces

Medical Journal, 1995, 45 (1): 50-4.

Moon CY, Wakly GK & Turner RT. Dose dependent effect

of Tamoxifen on long bones in growing rats, influence of

ovarian status. Endocrinology, Sept 1991, 129 (3): 1568-74.