COMPUTERIZED STEREOTACTIC BRAIN BIOPSIES: AN EXPERIENCE OF 15 PATIENTS AT AYUB TEACHING HOSPITAL

Authors

  • Sajid Nazir Bhatti
  • Shahid Ayub
  • Ahsan Aurangzeb
  • Anwar Ul Haq
  • M. Jamil
  • Johar Ali
  • Ayesha Ahmad
  • M. Kashif

Abstract

Background: Deep seated lesions of the brain cannot be approached by conventionalneurosurgical approach stereotactic system offers minimally invasive and accurateapproach to such lesions. This study was carried out with an objective to determine thesafety, efficacy and diagnostic yield of stereotactic biopsies of brain lesions using BrownRoberts-Wells (BRW) system. Methods: This study was carried out in patients withintracranial lesions at Ayub teaching hospital Abbottabad from September 1999 toOctober 2003. Suitable patients with intra cranial lesions underwent computerized stereotactic biopsy with BRW system. Tissue specimens were analyzed in histopathologydepartment of the Ayub Medical College and results were obtained. Data was analyzedvia computer software SPSS 8.0 version for windows. Results: Fifteen patients wereselected for stereotactic brain biopsy. Age ranged from 15 years to 54 years. Among them09 (60%) were male and 06 (40%) were female patients. Out come of the procedure washighly promising in terms of safety and positive diagnostic yield in 14 patients (93.3%),and histopathalogical validity of results (93.3%). Only one patient suffered mildneurological deficit (6.7%), one patient had inconclusive tissue diagnosis and invalidresult (6.7%). biopsy proven lesion was astrocytoma in 04 patients (26.7%), anaplasticastrocytoma in 04 (26.7%), gliomatosis in 02 (13.3%), tuberculomas in 03 (20.0%),metastatic adenocarcinomas in 01 (6.7%) and lymphoma in 01(6.7%). Conclusions: Weconclude that computerized stereotactic brain biopsy is safe and effective procedure witha high diagnostic yield at our center.Key words: Computerized stereotactic biopsy, brain, Brown-Roberts-Wells (BRW)system,

References

Horsly V, Clarke RH. The structure and function of

cerebellum examined by a new method. Brain 1908;

:45-125.

Descartes R. Discours de la methode. Leyen 1634.

Quinones-Molina R, Alaminos A, Molina H, Munoz J,

Lopez G, Alvarez L, et al. Computer-assisted CT-guided

stereotactic biopsy and brachytherapy of brain tumors.

Stereotact Funct Neurosurg. 1994;63(1-4):52-5.

Spiegel EA, Wycis HT, Marks M. Stereotactic apparatus

for operations on human brain.science 1947; 106:349-

Spiegel EA, Wycis HT. Stereoencephalotomy, part I,

New York; Grune and Stratton:1952.

Winkler D, Trantrakis C, Linder D, Richter A.

Improving planning procedure in brain biopsy. Coupling

frame-based stereaotaxy with navigational device STP

0. Minim Invasive Neurosurg 2003; 46:37-40.

Pecker J, Scarabin JM, Vallee B. Treatment of tumors

of pineal region; alive of stereotaxic biopsy. Surg Neurol

;341-8.

Regis J, Bouillet P, Rouby-Volot F. Pineal region tumors

and the role of stereotactic biopsy: review of mortality,

morbidity and diagnostic rates in 370 cases.

Neurosurgery 1996;39:907-14.

Liu Z, Yu X, Chen L, Du J, Yu X. Stereotactic biopsy

for intracranial deep lesions. Zhonghua yi xue za zhi

;82:225-8.

Chico-ponce de leon F, Perezpena-Diazcomti M,

Castro-Sierra E. Streotacticaly guided biopsies of brain

tumors. Childs Nerv Syst 2003;19:315.

Apuzzo MLJ, Chandrosoma PT, Cohend, Zee Cs,

Zelman V. computed imaging stereaotaxy. Experience

and prospective related to 500 procedures applied to

brain masses. Neurosurgery 1987; 20:930-7.

Osterag CB. Reliability of stereotactic brain tumor

biopsy. In: Lunsford LD: Modern stereotactic

neurosurgery. Boston;Martinus Nijhoff Publishing,

Sharma GR, Siddiqui H, Jooma R. Direct determination

of CT guided thalamotomy targets aided by an electronic

brain atlas: methods and operative results of 11 cases.

Pak J Neurosurg 2001;5:2-8

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