• Asghar Hussain Asghar
  • Sadia Rizvi
  • Shoab Shah
  • Muhammad Rauf
  • Ayub Khan
  • Javed Irfan


Background: Gated Single Photon Emission Computerized Tomography (SPECT) is a modalitywhich is helpful in the detection of wall motion, thickening and ejection fraction of left ventricle. Thepurpose of this study was to correlate the ungated and gated SPECT in evaluation of left ventricledysfunction. Method: It was a prospective study done at Institute of Radiotherapy and NuclearMedicine (IRNUM), Peshawar, in2001/02. 76 patients (47 male and 29 female) with an average age of52±11 years were inducted in this study. All patients underwent two days stress-rest Tc-99m MIBI(Methoxy Isobutyl Isonitrile) gated SPECT scan where 1110 MBq (30 mCi) was injectedintravenously. Eight frames gating technique (variable fixed temporal resolution) of ECG was used togate the cardiac cycle and whole acquisition was completed in 30 minutes. Results: This techniquevery well evaluated the perfusion as well as wall motion/thickening (W/M/T) status of left ventricle.Out of 76 scans, 30% were normal, 22% transmural infarct, 25% partial thickness infarct, and 22%reversible ischemia. By doing the 20 segmental analyses, total 1520 segments were analyzed thatrevealed good concordance of perfusion with W/M/T in 78% of segments while 22% segments showedpoor concordance. Out of these 22%, 12% were having more wall motion abnormalities than that ofperfusion, while in 10%, it was vise versa. Conclusion: Results of this study shows good correlationbetween gated and ungated SPECT for evaluation of left ventricle dysfunction (r = 0.73, p=0.01).Key Words:Tc-99m MIBI; Ischemic heart disease; Gated SPECT.


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