THE CRITICAL ANALYSIS ON DIAGNOSIS OF DISSEMINATED INTRAVASCULAR COAGULATION WITH SCREENING TESTS–A SCORING SYSTEM AND RELATED LITERATURE REVIEW

Authors

  • Bing H. Tang

Abstract

Background: The aim of this study is to assess confidence in the diagnosis of DisseminatedIntravascular Coagulation (DIC); to evaluate the clinical significance of the haemostatic tests; todisclose any respective associations of such tests with patients’ prognosis; and to review therelated literature. It is a retrospective case series study in Changhua Christian Hospital, Taiwan.Methods: Ninety-four patients’ data were analyzed. A scoring system was constructedretrospectively. Results: Hypotheses were postulated and proved. Each patient had a minimalscore of 5, whereas those patients who had reached (increased) their scores were to the full or evenover the maximal level (6 or 9) respectively. There was almost no correlation between age andProthrombin Time (PT). The correlation between age and platelet count, and that between age andfibrinogen were positively minor respectively, whereas that of Activated Partial ThromboplastinTime (APTT) was +0.208. The correlations between APTT and PT, platelet count, fibrinogenrespectively were significant. About 45.67% of patients had plasma fibrinogen >200 mg/dL, while22.23% had <100 mg/dL. A paradox was observed. The finding of such a limited package of thescreening tests was discussed. Related literature with regard to the clinical significance andpitfalls, as well as limitations and strengths of these haemostatic tests were reviewed andevaluated. Conclusion: There are 14 points of impression with clinical significance outlined.Keywords: DIC, Surgical Intensive Care Unit, Laboratory diagnosis, Haemostatic test, Screening test.

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