EXPERIMENTAL STUDY OF CADMIUM INDUCED HEPATIC TOXICITY
AbstractBackground: Cadmium is a modern toxic metal. It is a proven environmental pollutant and has hepatotoxic effects aswell. This study was carried out to look for hepatotoxicity of cadmium in rabbits. Methods: Forty rabbits divided intofour equal groups (3 experimental and 1 control) were used. Minimum Lethal dose and experimental dose of CadmiumSulphate were calculated. Group I was injected with half minimal lethal dose, Group II with experimental dose andGroup III with 30% specific bovine albumin, followed by experimental dose. The control group was injected withdistilled water. This treatment was continued for 12 weeks. During the experiment serum alanine transferase (S-ALT)and gamma glutamide transpeptidase (y-GT) were estimated twice, at intervals of 6 weeks and 12 weeks followed byautopsy at the end of the experiment. The liver was excised after sacrificing the animals. The tissue was processed forhistopathology. Results: A definite rise in the enzymes and changes in normal liver histology were observed.Conclusions: The cadmium induced lesions in the liver appear to be dose and time dependent. The findings of thisstudy suggest that cadmium has direct toxic effects on liver leading to hepatic damage. It is therefore recommendedthat the environmental cadmium pollution and uncontrolled industrial use of this metal must be controlled.
Stowe, H.D., Wilson, VI. < and Gover. R.A. (1972). Clinical
and morphological effects of oral cadmium toxicity in rabbits.
Arch. Pathol. P:389-405.
Singhal, R.L., Mirali, Z., and Hrdina, P.D. (1976). Aspects of
biochemical toxicology of cadmium. Federation Proc. 35: 75-
Piscator, M. (1964). On cadmium in normal human kidneys
together with a report on the isolation of metallothionein from
livers of Cd. Exposed rabbits. Nord. Hyg. Tidsker. 45: 76-82.
Friberg, L., and Kjellstorm, T. (1981). Disorder of Mineral
metabolism. Bronner, F. and Cobum, J.W. (eds). Ad. Press,
Inc. New York. Vol. 1:318-52.
Bernard, A., and Lauwerys, R. (1984). Cadmium in human
population. Experientia 40, Birkhauser Verlag, GH-4010
Basel/Switzerland. PP: 143-152.
JAMC, Vol 12, No. 1, 2000
Dudley, R.E., Gammal, L.M., and Klaassen, C D. (1985).
Cadimium-indueed Hepatic and renal injury in chronically
exposed rats. Likely role of hepatic cadmium-metallothionein
in nephrotoxicity. Toxicol. Appl. Pharmacol. 77:414-426.
Thomann, P., Achermann. H.R., and Ziel, R. (1981). Standard
animal models of hepatotoxicity, species differences and
relevance for man. Drug reactions and the liver. (M. Davis.,
J.M. Tredger., R. Villiams, Eds). PP: 321-328. Pitman Press,
Szasz. G. (1969). A kinetic photometric method for serum -
glutamyl transpeptidase. Vol. 15 No.2, pp: 124-136.
Kavvai, K., and Kimura, M. (1976). Morphological alterations
in experimental cadmium exposure with special reference to
the onset of renal lesion. In effects and dose-response
relationships of toxic metals. G.F. Nordberg. (ed.), PP.343-
Elsevier. Amsterdam/New York.