FREQUENCY OF DOUBLE EXPRESSOR LYMPHOMA IN A TERTIARY CARE HOSPITAL

Authors

  • Masroor Hassan Khyber Teaching Hospital Peshawar
  • Maria Tasneem Khattak Rehman Medical Institute Peshawar
  • Muhammad Ashraf Qamar Rehman Medical Institute Peshawar
  • Sarah Javed Rehman Medical Institute Peshawar
  • Syeda Uzma Saeed Rehman Medical Institute Peshawar

Abstract

Background: Accounting for 30% cases of all lymphoid neoplasms, Diffuse large B cell lymphoma (DLBCL) is the commonest lymphoma worldwide. It occurs over a wide age range and has diverse morphology, immunophenotype and clinical outcome. Objectives of the study were to determine the frequency of Double expressor lymphoma (DEL) in a tertiary care hospital. Methods: This descriptive cross-sectional study was carried out in the Department of Histopathology, Rehman Medical Institute Peshawar from June 1st to December 1st, 2018. A total of 88 newly diagnosed cases of diffuse large B-cell lymphoma (DLBCL); diagnosed on incisional or excisional biopsies were included in the study by non-probability consecutive sampling. Statistical analysis was carried out using SPSS-23. Quantitative variables were calculated as mean±SD. Qualitative variables were computed as frequency and percentages. Post stratification chi-square test was applied keeping p value equal or less than 0.05 as significance. Results: In our 88 cases of DLBCL, 56 (63.6%) were males and 32 (36.4%) were females. Age of patients ranged from 15yrs to 84yrs. Mean age was 50.8±15.2SD. Activated B-cell like (ABC) subtype of DLBCL constitute 51 cases (58%) while 37 cases (42%) were of germinal centre B-cell like (GCB) subtype. Nineteen cases (21.6%) were of DEL. Cervical node was the commonest site of involvement (n=17, 19.3%) followed by stomach (n=10, 11.4%) and tonsil (n=6, 6.8%). Out of 19 cases of DEL, 17 cases (89.5%) were of ABC type. DEL was found to have significant correlation with ABC subtype of DLBCL (p=0.002).  DEL had no correlation with gender (p=0.6), age (p=0.27), Mib-1 (p=0.36) and tumour site (p=0.42). Conclusion: The frequency of DEL in our study was 21.6% which is comparable to other studies who used similar cut-offs for c-Myc and BCL2 and similar criteria of inclusion as in our study. Significant association was found between DEL and ABC subtype of DLBCL. Keywords: Double protein lymphoma; Double expressor lymphoma; Diffuse large B cell lymphoma; Double hit lymphoma, Frequency

Author Biographies

Masroor Hassan, Khyber Teaching Hospital Peshawar

Assistant Professor, Department of Pathology

Maria Tasneem Khattak, Rehman Medical Institute Peshawar

Assistent professor and consultant histopathologist, Depatment of pathology

Muhammad Ashraf Qamar, Rehman Medical Institute Peshawar

Professor and consultant histopathologist, Depatment of pathology

Sarah Javed, Rehman Medical Institute Peshawar

Postgraduate Resident, Department of Pathology and blood bank

Syeda Uzma Saeed, Rehman Medical Institute Peshawar

Postgraduate Resident, Department of Pathology and blood bank

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Published

2021-02-20