SHORT-TERM EFFICACY OF INTRAVITREAL BEVACIZUMAB IN TREATMENT NAIVE PATIENTS- REAL WORLD EVIDENCE IN PAKISTAN

Authors

  • Hajra Arshad Malik Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan
  • Rayyan Sabih Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan
  • Maham Khalid Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan
  • Hina Khan Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan
  • Maha Asrar Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan
  • Aamir Asrar Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan
  • Muhammad Asif Department of Public Health, Government College University, Faisalabad

Abstract

Background: Anti-VEGF agents have been proven to be effective in treating macular oedema secondary to a multitude of pathological conditions. However, in large clinical trial settings, the results may be overstated. This study aimed to evaluate the short-term efficacy of intraocular Bevacizumab in consecutive patients with macular oedema being treated in a ‘real-world’ setting in Pakistan. Methods: A prospective study was conducted at Amanat Eye Hospital, Rawalpindi from August 2018 to November 2019. Thirty-five eyes of 29 patients with macular oedema were treated with monthly intravitreal Bevacizumab injections for three consecutive months. Best-corrected visual acuity (BCVA), and OCT parameters including central retinal thickness (CRT) and macular volume were assessed prior to the injections and then 4 weeks post the final injection and compared. Results: BCVA improved from 1.00±0.44 at baseline to 0.83±0.48 four weeks after the third intravitreal injection. CRT decreased significantly from 492.77±192.31 at baseline to 362.91±126.11 (p<0.05), and macular volume decreased significantly from 11.61±2.39 at baseline to 9.87±1.68 (p<0.05) four weeks after the third intravitreal injection. No systemic or ocular complications were observed during the course of the study. Conclusion: Treatment with intravitreal Bevacizumab injections was found safe and resulted in clinically and statistically significant improvement in SD-OCT parameters and visual acuity in patients with macular oedema secondary to various retinal pathologies. However, the improvement in a real-world setting was sub-optimal in comparison to larger clinical trials for specific diseases in the developed world

Author Biographies

Hajra Arshad Malik, Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan

Research Assistant,

Rayyan Sabih, Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan

Research Assistant

Maham Khalid, Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan

Research Assistant

Hina Khan, Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan

Consultant Ophthalmologist, Head of Ophthalmic Diagnostics MBBS, FCPS, FRCS; Fellowship in Medical Retina and Uveitis (UK)  

Maha Asrar, Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan

Research Assistant

Aamir Asrar, Medical Retina Clinic, Amanat Eye Hospital, Rawalpindi-Pakistan

Chief Consultant Ophthalmologist MBBS, MRCOphth, FRCS Fellowship in Vitreo-retinal surgery Fellowship in Corneo-refractive surgery

Muhammad Asif, Department of Public Health, Government College University, Faisalabad

Lecturer at Department of Public Health, GCUF.

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Published

2021-04-23

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