• Farhan Ali Dr Ruth Pfau Civil Hospital, Karachi, Pakistan.
  • Asra Waseem Dr Ruth Pfau Civil Hospital, Karachi, Pakistan.
  • Hina Sadiq Dr Ruth Pfau Civil Hospital, Karachi, Pakistan.
  • Areeba Rehman Dow University of Health Sciences




N-methyl-D-aspartate receptor (NMDAR) encephalitis, neuronal plasticity, chorea, rheumatic fever


N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis is an autoimmune syndrome with the development of antibody production against the NMDAR, affecting synaptic plasticity and cognition. It has a common association with ovarian teratomas with women being affected disproportionately. We present a case of an eight-year-old female child presented with complaints of fever, altered level of consciousness and choreiform movements. Owing to its common occurrence in the developing world, initially, rheumatic fever was kept in the differential diagnosis and was treated accordingly, but through a series of investigations, was diagnosed as a case of N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis. This case report urges the healthcare providers to keep Anti NMDAR encephalitis as a differential in their minds, while dealing with patients, having chorea as their main clinical manifestation. Owing to its rarity, we have primarily reported it here.

Author Biographies

Farhan Ali, Dr Ruth Pfau Civil Hospital, Karachi, Pakistan.

Department of Internal medicine, House officer.

Asra Waseem, Dr Ruth Pfau Civil Hospital, Karachi, Pakistan.

Dr Ruth Pfau Civil Hospital, Karachi, Pakistan, House Officer.

Hina Sadiq, Dr Ruth Pfau Civil Hospital, Karachi, Pakistan.

Department of Paediatrics, Dr Ruth Pfau Civil Hospital, Karachi, Pakistan, Resident Paediatrics. 


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