ASSOCIATION BETWEEN CAROTID INTIMA-MEDIA THICKNESS AND PHYSICAL ACTIVITY SCORES IN MIDDLE AGED PAKISTANI ADULTS – A HOSPITAL BASED STUDY

Salma Umbreen, Nasir Khan, Ghayyur Khan

Abstract


Background: The intima-media thickness of carotid arteries measured with B-mode ultrasound is a measurable index of the presence of atherosclerosis. Physical inactivity is known to be a risk factor for rapid onset and progression of atherosclerosis. Objective of the study was to evaluate the influence of leisure time physical activity on carotid intima media thickness in middle aged Pakistani population. Methods: This cross-sectional study was carried out at the Department of Diagnostic Radiology Holy Family Hospital in collaboration with the Department of Pathology and the Department of Internal Medicine from July to December 2009. Subjects were attendants of patients admitted to the Department of Internal Medicine. All individuals underwent B-mode carotid ultrasound and physical activity assessment was done by using IPA Questionnaires. Results: The study population consisted of 110 healthy men and women (male=64, mean age of 55.1±8.2 years and female=46, mean age of 58.6±6.7 years) with a mean physical activity of 438±97 (male=521±62 MET-minutes/weeks, female=394±162 MET-minutes/week). Results revealed that physical activity has significant association with the thickness of carotid intima media (p-value=0.042).  A total of 11 individuals (10%) had a carotid intima media thickness that was classified as a localized carotid artery plaque (males n=6 and female n=5). Conclusion: The proportion of time and level of physical activities is associated with thickness of intima media of common carotid artery, independently of age and established atherosclerotic risk factors.

Keywords: Ultrasound, intima-media thickness, carotid intima-media, atherosclerosis

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References


Bots ML, Baldassarre D, Simon A, de Groot E, O’Leary DH, Riley W, et al. Carotid intima media thickness and coronary atherosclerosis: weak or strong relations? Eur Heart J 2007;28:398–406.

Khan S, Ahmed SA, Nuri MMH, Khalid M, Rashid A, Mahmood A, et al. Role of Carotid Doppler in coronary artery disease. Pak Armed Forces Med J 2006;56:257–63.

Crouse JR 3rd. Thematic review series: patient-oriented research. Imaging atherosclerosis: state of the art. J Lipid Res 2006;47:1677–99.

Kadoglou NPE, Iliadis F, Liapis CD. Exercise and carotid atherosclerosis. Eur J Vasc Endovasc Surg 2008:35:264–72.

Kozakova M, Palombo C, Mhamdi L, Konrad T, Nilsson P, Staehr PB, et al. Habitual physical activity and vascular ageing in a young to middle aged population at low cardiovascular risk. Stroke 2007;38:2549–55.

Jafar TH, Jafary FH, Jessani S, Chaturvedi N. Heart disease epidemic in Pakistan: women and men at equal risk. Am Heart J 2005;150:221–6.

Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35:1381–95.

Wolinsky H, Glagov S. A lamellar unit of aortic medial structure and function in mammals. Circ Res 1967;20:99–111.

Howard G, Sharrett AR, Heiss G, Evans GW, Chambless LE, Riley WA, et al. Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. Stroke 1993;24:1297–304.

Pini R, Cavallini C, Bencini F, Silvestrini G, Tonon E, De Alfieri W, et al. Cardiovascular remodeling is greater in isolated systolic hypertension than in diastolic hypertension: the Insuffucuenza Cardiacanegli Anzianai Residenti (ICARE) a Dicomano study. J Am Coll Cardiol 2002;40:1283–9.

Salonen R, Seppänen K, Rauramaa R, Salonen JT. Prevalence of carotid atherosclerosis and serum cholesterol levels in Eastern Finland. Arteriosclerosis 1988;8:788–92.

Wagenknecht LE, D’Agostino R Jr, Savage PJ, O’Leary DH, Saad MF, Haffner SM. Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS). Stroke 1997;28:999–1005.

Ebrahim S, Papacosta O, Whincup P, Wannamethee G, Walker M, Nicolaides AN, et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British regional heart study. Stroke 1999;30:841–50.

Dwyer JH, Sun P, Kwong-Fu H, Dwyer KM, Selzer RH. Automated intima-media thickness: the Los Angeles atherosclerosis study. Ultrasound Med Biol 1998;24:981–7.

Wendelhag I, Liang Q, Gustavsson T, Wikstrand J. A new automated computerized analyzing system simplifies readings and reduces the variability in ultrasound measurement of intima-media thickness. Stroke 1997;28:2195–200.


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