CORRELATION BETWEEN GLYCATED HAEMOGLOBIN LEVELS AND RANDOM BLOOD GLUCOSE

Nasir Hussain Shah Kazmi, Saima Gillani, Saleem Afzal, Saad Hussain

Abstract


Background: Glycated haemoglobin or glycosylated haemoglobin (HbA1c) is a form of haemoglobin that is measured primarily to identify the average plasma glucose concentration over prolonged periods of time. Levels of HbA1c represent the average blood glucose levels of diabetic patients over the previous 120 days. The objective of this study was to see the correlation between HbA1c levels and random glucose levels. Methods: This descriptive study included 106 randomly selected patients with known diabetes from the outpatients department. Random sugar levels were measured by using venous blood samples. HbA1c levels were measured in venous blood by BIO-RAD D-10 HPLC Method. Data were recorded on a proforma. Pearson’s correlation was applied to find out any significant correlation between the glycated haemoglobin levels and the random blood glucose levels. Results were plotted on simple scatter plot and p<0.01 was considered significant. Conclusions: A significant linear positive correlation exists between levels of HbA1c and random blood sugar.

Keywords: Diabetes, HbA1c, blood glucose levels, HbA1c

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References


Sattley M. The history of Diabetes. Available at: http://diabeteshealth.com/read/2008/12/17/715/the-history-of-diabetes

Banting FG, Best CH, Cambell WR, Fletcher AA. Pancreatic extracts in the treatment of diabetes mellitus. Can Med Assoc J 1992;12:141–6.

Rahbar S, Blumenfeld O, Ranney HM. Studies of an unusual hemoglobin in patients with diabetes mellitus. Biochem Biophys Res Commun1969;36: 838–43.

Nathan DM, Kuenen J, Borg R, Zheng H, Schoenfeld D, Heine RJ; A1c-Derived Average Glucose Study Group. Translating the A1c assay into estimated average blood glucose values. Diabetes Care 2008;31:1473–8.

Massi-Benedetti M. Changing targets in the treatment of type 2 Diabetes. Curr Med Res Opin 2006;22(Suppl 2):S5–13.

Nathan DM, Turgeon H, Regan S. Relationship between glycated hemoglobin levels and mean glucose levels over time. Diabetolgia 2007;50:2239–44.

Koeing RJ, CM, Jones RL, Saudek C, Lehrman M, Cerama A. Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus. N Engl J Med 1976;295:417–20.

HemoglobinA1c Fact Sheet. Michigan Diabetes Research and Training Center. Available at: https://www.med.umich.edu/ mdrtc/cores/chemcore/hemoa1c.htm. [Retrieved 2007-12-26]

Sidorenkov G, Haaijer-ruskamp FM, de ZeeuwD, Denig P. A longitudinal study examining adherence to guidelines in diabetes care according to different definitions of adequacy and timeliness. PloS One 2011;6(9):e24278.

Santos-Rey K, Fernandez-RiejosP, Mateo J, Sanchez-Margalet V, Goberna R. Glycated hemoglobin vs. the oral glucose tolerance test for the exclusion of impaired glucose tolerance in high risk individuals. Clin Chem Lab Med 2010;48(12):1719–22.

Strattton IM, Adler AI, Andrew WN, Mathews DR, Manley SE, Cull CA, et al. Association of glycemia with macrovascular and microvascular complications of type 2 diabetes(UKPDS 35):prospective observational study. BMJ 2000;321:405–11.

Mostafa SA, Davies MJ, Webb D, Gray LJ, Srinivasan BT, Jarvis J, et al. The potential impact of using glycated hemoglobin as the preferred diagnostic tool for detecting type 2 diabetes mellitus. Diabet Med 2010;27:762–9.

Sikaris K. The correlation of Hemoglobin A1c to blood glucose. J Diabetes Sci Technol 2009;3:429–38.

Improving outcomes in type 2 diabetes. MeReC Bulletin June 2011;21(5). Available at: http://www.npc.nhs.uk/merec/ cardio/diabetes2/merec_bulletin_vol21_no5.php

JBS2: Joint British Societies. Guidelines on prevention of cardiovascular disease in clinical practice. Heart 2005;91(Suppl 5):v1–52.

American Diabetes Association. Standards of Medical Care in Diabetes-2010. Diabetes Care 2010;33:S11–S61.

Alemzadeh R, Ali O. Glycated hemoglobin (HbA1c). Diabetes mellitus. In: Kligman RM, Stanton BF, Schor NF, (Eds) Nelson text book Pediatrics. 19th ed. India: Thompson Press; 2012.p. 1984.

KilPatrick ES, Rigby AS, Atkin SL. Variability in the relationship between mean plasma glucose and HbA1c: implications for the assessment of glycemic control. Clin Chem 2007;53:897–901.

Azim W, Omair M, Khan MQA, Shaheen N, Saad Azim S. Correlation between Glycated Haemoglobin and random Plasma glucose levels for the screening of Diabetes Mellitus. Int J Pthol 2010;8(2):59–62.

Sacks DB. Correlation between hemoglobin A1c and average blood glucose concentration. J Diabetes Sci Technol 2007;1(6):801–3.


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