ASSOCIATION OF MATERNAL HYPERTENSION WITH PLACENTAL ABRUPTION

Samina Naseem Khattak, Farhat Deeba, Attiya Ayaz, Muhammad Irfan Khattak

Abstract


Background: Placental abruption is one of the leading causes of maternal mortality and morbidity.
Many causes predispose an expecting mother to placental abruption, such as trauma, previous
history, smoking, ethnicity and hypertension. The present study concentrated on maternal
hypertension as a cause of abruption. Methods: All subjects of this comparative study underwent a
complete obstetrical clinical workup comprising history, general physical examination, abdominal
and pelvic examination, and relevant investigations. The maternal condition was assessed and
managed according to established labour ward protocols, which included both pharmacological and
surgical intervention. Patients were allotted various subgroups for detailed data analysis and
comparative analysis. Results: A total of 50 cases and 50 controls for placental abruption were
studied during the study period. Both groups were compared based on parity, gestational age,
proteinurea, haemoglobin, and hypertension. Mean systolic blood pressure (SBP) of cases in this
study was 155±7.8 mmHg versus mean SBP for controls was 120±14 mmHg. Mean diastolic blood
pressure (DBP) of the cases was 104±6.6 mmHg compared to controls where mean DBP was 71±11
mmHg. Among the controls, 45 (90%) had blood pressures in the normal range. There was
statistically significant differences between cases and controls with respect to hypertension (p<0.01).
Conclusion: Placental abruption is strongly associated with maternal hypertension.
Keywords: Placental Abruption, Hypertension, Maternal Morbidity, Antepartum Haemorrhage (APH)

Full Text:

PDF

References


Ananth CV, Getahun D, Peltier MR, Smulian JC. Placental

abruption in term and preterm gestations: evidence for

heterogeneity in clinical pathways. Obstet Gynecol

;107:785–92.

Ananth CV, Savitz DA, Bowes WA, Jr., Luther ER. Influence of

hypertensive disorders and cigarette smoking on placental

abruption and uterine bleeding during pregnancy. Br J Obstet

Gynaecol 1997;104:572–8.

Ananth CV, Savitz DA, Williams MA. Placental abruption and

its association with hypertension and prolonged rupture of

membranes: a methodologic review and meta-analysis. Obstet

Gynecol 1996 ;88:309–18.

Cnattingius, S. Maternal age modifies the effect of maternal

smoking on intrauterine growth retardation but not on late fetal

death and placental abruption. Am J Epidemiol 1997;145:319–

Hibbard BM, Hibbard ED. Aetiological Factors in Abruptio

Placentae. Br Med J 1963;2(5370):1430–6.

Tasleem H, Tasleem S, Adil MM, siddique M, Waheed K. Corelation of pregnancy induced hypertension with placental

abruption and effect of antihypertensive therapy. Rawal Med J

;30:59–61.

Kramer MS, Usher RH, Pollack R, Boyd M, Usher S. Etiologic

determinants of abruptio placentae. Obstet Gynecol

;89:221–6.

Rasmussen S, Irgens LM, Bergsjo P, Dalaker K. The occurrence

of placental abruption in Norway 1967–91. Acta Obstet Gynecol

Scand 1996;75:222–8.

Sheiner E, Shoham-Vardi I, Hadar A, Hallak M, Hackmon R,

Mazor M. Incidence, obstetric risk factors and pregnancy

outcome of preterm placental abruption: a retrospective analysis.

J Matern Fetal Neonatal Med 2002;11(1):34–9.

Williams MA, Lieberman E, Mittendorf R, Monson RR,

Schoenbaum SC. Risk factors for abruptio placentae. Am J

Epidemiol 1991;134:965–72.

Pritchard JA, Mason R, Corley M, Pritchard S. Genesis of severe

placental abruption. Am J Obstet Gynecol 1970;108(1):22–7.

Ananth CV, Oyelese Y, Yeo L, Pradhan A, Vintzileos AM.

Placental abruption in the United States, 1979 through 2001:

temporal trends and potential determinants. Am J Obstet Gynecol

;192:191–8.

Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol

;108:1005–16.

Mackenzie AP, Schatz F, Krikun G, Funai EF, Kadner S,

Lockwood CJ. Mechanisms of abruption-induced premature

rupture of the fetal membranes: Thrombin enhanced decidual

matrix metalloproteinase-3 (stromelysin-1) expression. Am J

Obstet Gynecol 2004;191:1996–2001.

Liquat NF, Shoaib T, Shuja S. A study of abruptio placentae. J

Surg Pak 2006;11(1):27–30.


Refbacks

  • There are currently no refbacks.


Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]