ASSOCIATION OF LEPTIN WITH TYPE 2 DIABETES IN NON-OBESE SUBJECTS

Ahsan Kazmi, Khalid Mehmood Tariq, Rizwan Hashim

Abstract


Background: South Asians have a high tendency to develop type 2 diabetes even at low BMI. We
evaluated serum leptin levels in a group of non-obese type 2 diabetics. Methods: An observational study
conducted on 90 subjects, 55 with Type 2 diabetes mellitus, and 35 normal controls (non-diabetics).
BMI, waist circumference, serum leptin, and serum glucose were measured. The correlation between
these variables was studied by multiple regression analysis. Results: Serum leptin levels were positively
correlated with BMI in obese (r=0.976) and non-obese diabetics (r=0.956). Serum leptin was related
with diabetes (r= -0.153, p=0.001). Serum leptin was highly correlated with waist circumference in
obese than non-obese diabetics, (r=0.753). Mean serum leptin level was 21.4 ηg/ml in non-obese
diabetics and 34.9 ηg/ml in diabetic group. It is even lower than the non-obese, non-diabetics (23.3
ηg/ml). Multivariate linear regression analysis between leptin and age, weight, BMI, waist circumference
in patients shows only a strong association with BMI in diabetics (p=0.0001), while in non-diabetic it
was not significant (p=0.07). Serum leptin was high in diabetics taking oral hypoglycaemic (37.8±19.1
ηg/ml), while it was low in diabetics taking insulin injections (29.3±24.2 ηg/ml). Conclusion: Low
leptin levels are associated with type 2 diabetes mellitus independent of changes in BMI.
Keywords: Leptin, BMI, waist circumference, type-2 diabetes mellitus, serum glucose.

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References


Diabetes in people of South Asian origin in the UK. Available at:

http://diabetesuffolk.com/UnderstandingDiabetes/Diabetesin

SouthAsians.htm

Boden G. Pathogenesis of type 2 diabetes, insulin resistance.

Endocrinol Metabo Clin North Am 2001;30:801–15.

Boden G. Role of fatty acids in the pathogenesis of insulin

resistance and NIDDM. Diabetes 1997;46:3–10.

Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM.

The role of lipids in the pathogenesis of muscle insulin

resistance and β-cell failure in type II diabetes and obesity. Exp

Clin Endocrinol Diabetes 2001;109(Suppl-2):S189–S201.

Considine RV, Sinha MK, Heinman ML, Kriauciunas

A, Stephens TW, Nyce MR, et al. Serum immunoreactive

leptin concentrations in normal-weight and obese humans. N

Engl J Med 1996;334:292–5.

Sivitz WL, Walsh SA, Morgan DA, Thomas MJ, Haynes

WG. Effects of leptin on insulin sensitivity in normal rats.

Endocrinol 1997;138:3395–401.

Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Wnters

D, Boone T, et al. Effects of the obese gene product on body

weight regulation in ob/ob mice. Science 1995;268:540–3.

Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron

MJ. Acute stimulation of glucose metabolism in mice by

leptin treatment. Nature 1997;389:374–7.

Kieffer TJ, Habener JF. The adipoinsular axis: effects of

leptin on pancreatic β-cells. Am J Physiol Endocrinol

Metab 2000;278(1):E1–E14.

Al-Shoumer KA, Vasanthy BK, Makhlouf HA, Al-Zaid MM.

Leptin levels in Arabs with primary hyperthyroidism. Ann

Saudi Med 2000;20(2):113–8.

Clement K, Lahlou N, Ruiz J, Hager J, Bougnères

P, Basdevant A, et al. Association of poorly controlled

diabetes with low serum leptin level in morbid obesity. Int J

Obes1997;21:556–61.

Roden M, Ludwig C, Nowotny P, Schneider B, Clodi

M, Vierhapper H, et al. Relative hypoleptinemia in patients

with type 1 and type 2 diabetes mellitus. Int J Obesity Relat

Metab Disoord 2000; 24:976–81.

J Ayub Med Coll Abbottabad 2012;24(3-4)

http://www.ayubmed.edu.pk/JAMC/24-3/Kazmi.pdf 189

Widjaja A, Stratton IM, Horn R, Holman RR, Turner R,

Brabant G. UKPD 20: Plasma leptin, obesity, and plasma

insulin in type 2 diabetes subjects. J Clin Endocrinol Metab

;82:654–7.

Haffner SM, Stern MP, Miettinen H, Wei M, Gingerich RL.

Leptin concentrations in diabetic and non-diabetic MexicanAmericans. Diabetes 1996;45:822–4.

Guler S, Cakir B, Demirbas B, Gursony G, Serter R, Araf Y.

Leptin concentrations are related to glycemic control, but do

not change with short-term oral antidiabetic therapy in female

patients with type 2 diabetes. Diabetes Obes Metab

;2:313–6.

Schwartz MW, Prigeon RL, Kahn SE, Nicolson M, Moore

J, Morawiecki A, et al. Evidence that plasma leptin and

insulin levels are associated body adiposity via different

mechanisms. Diabetes Care 1997;20:1476–81.

Soliman AT, Omar M, Assem HM, Nasr IS, Rizk MM, El

Matary W, et al. Serum leptin concentrations in children with

type 1 diabetes mellitus: relationship to body mass index,

insulin dose, and glycemic control. Metabolism 2002;51:292–6.

Sivitz WI, Walsh S, Morgan D, Donohoue P, Haynes W,

Leibel RL. Plasma leptin in diabetic and insulin-treated

diabetic and normal rats. Metabolism. 1998;47:584–91.

Havel PJ, Uriu-Hare JY, Liu T, Stanhope KL, Stern JS, Keen

CL, et al. Marked and rapid decreases of circulating leptin in

streptozotocin diabetic rats: reversal by insulin. Am J Physiol

;274(5 pt 2):R1482–91.

Marita AR, Sarkar JA, Rane S. Type 2 diabetes in non-obese

Indian subjects is associated with reduced leptin levels: study

from Mumbai, Western India. Mol Cell Biochem.

;275(1–2):143–51.

Kirel B, Dogruel N, Korkmaz U, Kilic FS, Ozdamar K, Ucar

B. Serum leptin levels in type 1 diabetes and obese children:

relation to insulin levels. Clin Biochem 2000;33:475–80.

Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang

Y, et al, Leptin levels in human and rodent: Measurement of

plasma leptin and ob RNA in obese and weight-reduced

subjects. Nat Med 1995;1:1155–61.

Horwitz D, Kuzuya H, Rubenstein AH. Circulating serum Cpeptide. N Engl J Med 1979;295:207–9.

Ruhl CE, Everhart JE. Leptin concentrations in the United

States: relations with demographic and anthropometric

measures. Am J Clin Nutr 2001;74(3):295–301.

Kalhan R, Puthawala K, Agarwal S, Amini SB, Kalhan SC.

Altered lipid profile, leptin, insulin, and anthropometry in

offspring of South Asian immigrants in the United States.

Metabolism 2001;50:1197–202.


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