EFFECTS OF CIPROFLOXACIN AND ZINC CHLORIDE IN ADULT ALBINO RAT AND PRE-NATAL CONCEPTUS

Muhammad Aslam Channa, Muhammad Ashfaq, Abdul Lateef Jokhio, Muhammad Zaheer Khan, Mir Muhammad Sahito

Abstract


Background: Administration of quinolone therapy is controversial during growing age as
stated by earlier authors. The flouroquinolones are currently not indicated for young
children because of arthropathy and adverse effect as new born shown by studies. However
the effects of ciprofloxacin and ZnCl2 on prenatal conceptus have remained undocumented.
The present study was designed to compare the effects on conceptus after maternal
ingestion of ciprofloxacin and ZnCl2 using Wastar albino rats. Methods: Ciprofloxacin and
ZnCl2 was administrated to pregnant female albino rats. Ciprofloxacin with a dose of 20
mg/Kg bodyweight and ZnCl2 120 µg/100 gm bodyweight two times therapeutic dose for
10 days (from day 8–18 of pregnancy). Each animal was weighted on day 1, day 8 and day
18 of pregnancy. Abortion resulted on day 18th of pregnancy. Each group of pregnant
animals were sacrificed on day 18 of gestation by over dose of either anaesthesia, abdomen
opened, uterus and both cornua containing conceptus identified, removed, there weight
recorded, crown rump length was measured and was compared with similar value of control
animals. The results were statistically analysed to find out the significance. Results: The
ciprofloxacin induces a mordanting effect as obviated by increased basophilia. Our study
reveals that ciprofloxacin administered in maternal, decreased maternal body weight to
38.4±0.9 gm. However simultaneous ZnCl2 maintained the body weight to 41.4±0.7 gm,
while ZnCl2 increased the body weight to 46.5±2.25 gm. The body weight and Crown
Rump length (CR Length) in conceptus decreased by 4.52±0.10 gm and 3.06±0.09 Cm
respectively. That ciprofloxacin and ZnCl2 administration maintained the body weight and
CR length by 5.46±0.09 gm and 3.79±0.13 Cm respectively. That ZnCl2 administration
increased the body weight and CR length by 6.71±0.05 gm and 4.15±0.08 Cm respectively.
Conclusion: Prenatal administration of Ciprofloxacin caused reduction in growth rate and
CR length, and ZnCl2 maintained body weight and CR length and growth of the rat
conceptus.
Keywords: Ciprofloxacin, ZnCl2, body weight, crown rump length, conceptus

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