A MORPHOLOGICAL STUDY OF CELIAC, SUPERIOR MESENTERIC AND INFERIOR MESENTERIC ARTERIES IN ATHEROSCLEROSIS

Amjad Naeem, Nadia Nasim, Umaira Ihsan, Atika Masood

Abstract


Background: Depolymerisation of acid-mucopolysaccharides results in the loss of metachormasia of
the ground substance followed by visible fibre crumbling, complete dissolution and replacement by
lipid droplets and cholesterol. The objective of this study was to assess the distribution of different
atherosclerotic lesions in celiac, superior mesenteric and inferior mesenteric arteries relation to age and
sex. Methods: A prospective descriptive observation study was conducted at Mortuary of King Edward
Medical University Lahore, and Department of Pathology Allama Iqbal Medical College Lahore. A
total of 30 human autopsies were carried out. Celiac, Superior mesenteric and inferior mesenteric
arteries were taken out and opened length-wise. One to four areas of tissue were taken from each artery
for histological examination. Slides were prepared from each paraffin block. Sections were stained with
haematoxylin and eosin. Special stains were performed on sections to display each component of
atherosclerosis. Results: The fibrolipid plaques were seen in 6 cases. The complicated lesions were
present in 5 cases. Of these, 4 showed ulceration and 1 showed thrombus formation. The calcified
lesions were observed in 5 cases. The morphological changes in media and elastica were present in 4
cases. In superior mesenteric artery fatty streaks were present in 8 cases. The fibrolipid plaques were
confirmed in 5 cases. Three cases showed ulceration, 1 case showed intimal vascularisation,
haemorrhage, and thrombus formation. The calcified lesions were present in 2 cases. The
morphological changes in media and elastica were seen in 4 cases in anterior mesenteric artery. Fatty
streaks were present in 8 cases. The fibrolipid plaques were grossly observed in 6 cases. The
complicated lesions were present in 4 cases; of these, 3 cases showed ulceration, and 1 showed intimal
vascularisation and haemorrhage along with thrombus formation. The calcified lesions were present in
3 cases. The morphological changes in media and elastica were present in 4 cases. Conclusion: This
data indicates the incidence of ischemic changes in abdominal viscera due to atherosclerotic narrowing.
Keywords: Celiac, Superior, Inferior, mesenteric, atherosclerosis, arteries

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