EFFECTS OF SIMVASTATIN ON LIPID PROFILE AND NERVE CONDUCTION VELOCITY IN OBESE SPRAGUE DAWLEY RATS

Asma Jabeen, Umar Ali Khan, Ghulam Mustafa Lodhi

Abstract


Background: The incidence of obesity is increasing worldwide. The lipid derangements and decrease in
nerve conduction velocity are important complications for which a number of treatment options are
being considered. In this study, Simvastatin, a hydroxyl methyl glutaryl coenzyme A reductase inhibitor
is studied for its effects on these complications of obesity. Methods: The study was a randomised
control trial conducted at Islamic International Medical College, Rawalpindi in collaboration with
Railway General Hospital, Rawalpindi, and National Institute of Health, Islamabad. Ninety adult male
Sprague Dawley rats were divided into three groups with thirty rats in each group. One group of rats was
taken as control with normal diet while other two groups were given High Fat Diet (HFD) for the whole
study period, i.e., 10 weeks. One of the HFD group was given Simvastatin along with high fat diet for
four weeks. Lipid profile was done by enzymatic colorimetric method. Conduction velocity of sciatic
nerve was determined with the help of PowerLab® data acquisition system. Results: The two groups
with HFD showed more than 25% increase in weight at the end of study as compared to control group.
HFD group showed significantly higher lipid profile and decreased sciatic nerve conduction velocity
when compared with control. The group that was given Simvastatin showed significant improvement in
lipid profile and increased sciatic nerve conduction velocity after 4 weeks when compared with the group
that was given HFD without any intervention. Conclusions: Simvastatin is effective for improving the
lipid profile and sciatic nerve conduction velocity in HFD induced obesity.
Keywords: Obesity, Simvastatin, nerve conduction velocity

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