Ali Gul Tunio, Moosa Khan, Dial Das, Ghulam Sarwar


Background: Major depressive disorder is a serious and disabling illness in the world and is
common chronic and recurrent disorder. It is the fourth most important cause of worldwide loss in
disability. Methods: This was prospective and open-label study, study conducted in JPMC,
Karachi, to evaluate the efficacy and adverse effects in major depressive disorder individuals. A
total of 40 patients irrespective of the gender, aged 18 years up to 65 years were enrolled from
OPD of Psychiatry Department. Follow-up visits were carried out fortnightly after making
evaluation of symptoms at baseline visit (day 0), follow-up continued till 90 days when the results
were compiled. Results: Statistically significant (p<0.05) results were observed in all the
parameters at the end of study, i.e., day 90. Conclusion: Among all the symptoms of major
depressive disorder, trazodone proved to be more effective in controlling insomnia.
Keywords: Trazodone, major depressive disorder, side effects, anxiolytics

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