EFFECTS OF ‘OLEA EUROPEA’ EXTRACT ON VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION, LIVER AND KIDNEY FUNCTION IN RABBITS

Muhammad Jan

Abstract


Background: Peptic ulcer is mostly produced due to the over production of gastric acid. This study was
undertaken to find out the effects of extract from the leaves of medicinal plant Olea europea (which
contains documented natural Calcium channel blocker) on volume and acidity of Carbachol induced
gastric section. Its effects were also observed on liver and kidney function. Methods: Thirty rabbits of
local breed, weighing 1–1.5 kg were used. The animals were kept on fasting for 48 hours, after that the
pylorus of each animal was ligated. Carbachol 600 μg/kg body weight and extract from the leaves of
Olea europea 500 mg/kg body weight were administered intraperitoneally to group A and B
respectively. The extract was also administered in the same dose to group C for 45 days twice daily
intraperitoneally to observe its effects on liver and kidney function. Results: The extract reduced the
volume, free and total acidity of gastric secretion, which were statistically highly significant when
compared with Carbachol (p<0.001). When the differences of means for both the liver and kidney
function were compared with that of control group, all these were found statistically non-significant
indicating that the extract has no adverse effects on these organs regarding all parameters included in
study. Conclusion: Extract can be used effectively and safely in the treatment of hyper gastric acidity
conditions and peptic ulcer after evaluation of its effects in human subjects.
Keywords: Medical plants, Olea Europea

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