CLASSICAL PRESENTATION OF DARIER’S DISEASE: A RARE DISORDER OF KERATINISATION

Atiya Mahboob, Faryal Yaqub, Zahid Shahzad, Manaal Afzaal, Moazzum Hanif, Deeba Sattar Khan, Riffat Nasim, Aleena Khan

Abstract


Keratosis follicularis or Darier’s disease (DD), a rare autosomal dominant disorder is
characterised clinically by appearance of multiple, prurutic, discrete, scaly papules affecting
seborrheic areas coupled with palmar pits, nail changes and mucosal involvement. Histologicaly
the lesions show suprabasal clefts with acantholytic and dyskeratotic cells. We report a case of 35
years old woman with typical clinical and histological features of Darier’s disease.
Keywords: Autosomal dominant, palmar pits, suprabasal clefts, Darier’s disease

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References


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