Ehtesham I. Khan, Rehana S. Kamal, Hameed Ullah


Background: It is well documented that surgery is associated with increased anxiety, which has an
adverse impact on patient’s outcome. This study was designed to assess the anxiolytic effect of
midazolam in pre-anaesthetic medication by using clinical and platelet aggregation profiles.
Methods: Sixty ASA I and II female patients aged between 35 and 60 years undergoing elective
abdominal hysterectomy were randomly divided into two equal groups. Group I received placebo as
pre-medication while group II received 0.15 mg/kg midazolam as pre-medication 1 hour
preoperatively. They were monitored for visual analogue scale (VAS) for anxiety, observer’s anxiety
criteria, sedation score, blood pressure, heart rate and platelet aggregation profile immediately before
and 1 hour after pre-medication. Results: There was statistically significant difference with respect
to VAS of anxiety, observer’s anxiety criteria, sedation scores, systolic and diastolic blood pressure
(p<0.05). Heart rate was higher in the midazolam group but this was not statistically significant.
There was no statistical significant difference in platelet aggregation profile in the two groups.
Conclusion: Findings of the study suggest midazolam is a good anxiolytic for pre-medication and its
effect on platelet aggregation profile needs to be further evaluated.
Keywords: Pre-medication, Widazolam, Anxiolysis, Platelet aggregation

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