CORRELATION BETWEEN PLASMA THYROID HORMONES AND LIVER ENZYMES LEVEL IN THYROTOXIC CASES AND CONTROLS IN HAZARA DIVISION

Tariq Mehmood Khan, Saqib Malik, Inayat Ullah Diju

Abstract


Background: Thyrotoxicosis is defined as increased synthesis and secretion of thyroid hormones;
when associated with defused goitre it is known as grave’s disease. Hepatic changes in thyrotoxiosis are
fatty changes, cirrhosis and centrilobular necrosis, resulting in elevated serum levels of liver specific
enzymes ALT, AST and ALK. Objective of the study was to determine a correlation between plasma
levels of 3 liver enzymes, and thyroid hormones in thyrotoxic cases, and matched controls in Hazara
Division. Methods: This study was conducted at Ayub Teaching Hospital Abbottabad from 1st July
2004 to 30th June 2007. The controls were selected from staff and students of Ayub Medial College
Abbottabad. Fifty cases of thyrotoxicosis and 50 controls were included in this study by convenience
sampling. Their thyroid profile for T3, T4, TSH and liver enzymes profile for ALT, AST, ALK were
determined and analysed for a correlation. Results: Mean T3 of cases was 5.23±1.95 and of controls
1.95±0.35. Mean T4 of case was 248.88±62.75, and of controls was 113.40±19.01. Mean TSH of cases
was 0.07±0.25 and that of controls was 2.24±0.80. Mean ALT of cases was 38.78±4.96 while that of
controls was 23.98±5.27. Mean AST of cases was 39.76±5.05 and of controls was 26.52±4.49. Mean
ALK of cases was 299.68±22.32 and of controls was 155.10±37.07. Conclusion: Although liver
enzymes levels were slightly elevated in many thyrotoxic cases, no significant correlation emerged
between any of the thyroid hormones and any of the liver enzymes, either in cases or controls.
Keywords: Thyrotoxiosis, Liver enzymes, Grave’s disease, Hyperthyroidism

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References


Cooper DS. Hyperthyroidism. Lancet 2003;362:459–68.

Weetam AP, McGregor AM. Autoimmune thyroid disease:

Developements in our understanding. Endocr Rev

;5:309–55.

Botazzo GF, Doniach D. Autoimmune thyroid disease. Annu

Rev Med 1986;37:353–9.

Malik R, Hodgson H. The relationship between the thyroid

gland and the liver. QJM 2002;95:559–69.

Kubota S, Amino N, Matsumoto Y, Ikeda N, Morita S, Kudo

T, et al. Serial changes in liver function tests in patients with

thyrotoxicosis induced by Grave’s disease and painless

thyroiditis. Thyroid 2008;18:283–7.

Huang MJ, Liaw YF. Clinical associations between thyroid

and liver diseases. J Gastroenterol Hepatol 1995;10:344–50.

Khan A, Khan M M A, Ahktar S. Thyroid disorders, Etiology

and Pevelance. J Med Sci 2002;2(2):89–94.

Biscoveanu M, Helsinki S. Abnormal results of liver function

tests in patients with Grave’s disease. Endocr Pract

;6(5):367–9.

Bayraktar M, Van Thiel DH. Abnormalities in measures of

liver function and injury in thyroid disorders.

Hepatogastroenterology 1997;44:1614–8.

Thompson NP, Leader S, Jamieson CP, Burnham WR,

Burroughs AK. Reversible jaundice in PBC due to

hyperthyroidism. Gastroenterology 1994;106(5):1342–3.


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