VAGINOPLASTY BY USING AMNION GRAFT IN PATIENTS OF VAGINAL AGENESIS ASSOCIATED WITH MAYOR-ROKITANSKYKUSTER-HAUSER SYNDROME

Iram Sarwar, Ruqqia Sultana, Rahat Un Nisa, Iftikhar Qayyum

Abstract


Background: Vaginal agenesis is congenital anomaly of the female genital tract and may occur as
isolated developmental defect or as part of a complex of anomalies. The aim of this study was to
determine the effectiveness of vaginoplasty by using amnion as graft in the creation of neovagina for
patients with Mayor-Rokitansky-Kuster-Hauser Syndrome. Methods: this is a retrospective study of 28
cases of vaginal agenesis associated with Mayor-Rokitansky-Kuster-Hauser Syndrome, over the period
of 20 years, in which vaginoplasty was done by modified McIndoe procedure by using amnion as graft.
Results: vaginoplasty using amnion graft was successfully performed in all except one case in which
rectum got opened and procedure was abandoned after the repair of rectum. The functional results were
quite satisfactory. Except one case none had any significant peri-operative complication. Post surgical
results were acceptable to the patients sexually and aesthetically. Conclusion: Although new
techniques of vaginoplasty have evolved over the years using laparoscopic approach and by use of
different materials as graft, vaginoplasty with amnion graft is still a safe and effective procedure to treat
patients of vaginal agenesis. The technique is simple and safe and provides a satisfactory and functional
vagina in majority of the patients.
Keywords: vaginoplasty, amnion graft, vaginal agenesis, vaginal atresia, Mayor-RokitanskyKuster-Hauser Syndrome

Full Text:

PDF

References


Saxena AK, Herman MI. Vaginal Atresia. Webpage. Cited

June 02, 2009. Available at: http://emedicine.medscape.com/

article/954110-print.

Saraf S, Saraf P. McIndoe vaginoplasty: revisited. Internet J

Gynecol Obstetr 2007;6(2). Online Journal. Cited August 18,

Available from: http://www.ispub.com/journal/the

_internet_journal_of_gynecology_and_obstetrics/volume_6_

number_2_6/article/mcindoe_vaginoplasty_revisited.htmls.

Gupta NP, Ansari MS. Mayer-Rokitansky-Kuster-Hauser

(MRKH) syndrome–a review. Indian J Urol 2002;18:111–6.

Kirsch AJ, Kaye JD, Carter SM, Gross SJ. Mayer-Rokitansky

syndrome. Webpage. Cited June 02, 2009. Available from:

http://emedicine.medscape.com/article/953492-print.

Chohan A, Burr F, Mansoor H, Falak T. Amnion graft in

vaginoplasty–an experience at 3 teaching hospitals of Lahore.

Biomedica 2006;22(1):21–4.

Fotopoulou C, Sehouli J, Gehrmann N, Schoenborn I,

Lichtenegger W. Functional and anatomical results of

amnion vaginoplasty in young women with MayerRokitansky-Kuster-Hauser syndrome. Fertil Steril 2009;

(Epub ahead of print).

Rothman D. The use of peritoneum in the construction of a

vagina. Obstet Gynecol 1972;40:835–8.

Jackson ND, Rosenblatt PL. Use of interceed absorbable

adhesion barrier for vaginoplasty. Obstet Gynecol

;84:1048–50.

Noguchi S, Nakatsuka M, Sugiyama Y, Chekir C, Kamada

Y, Hiramatsu Y. Use of artificial dermis and recombinant

basic fibroblast growth factor for creating a neovagina in a

patient with Mayer-Rokitansky-Kuster-Hauser syndrome.

Hum Reprod 2004;19:1629–32.

Lin WC, Chang CYY, Shen YY, Tsai HD. Use of autologous

buccal mucosa for vaginoplasty: a study of eight cases. Hum

Reprod 2003;18:604–7.

Cai B, Zhang JR, Xi XW, Yan Q, Wan XP. Laparoscopically

assisted sigmoid colon vaginoplasty in women with MayerRokitansky-Kuster-Hauser syndrome: feasibility and short

term results. BJOG 2007;114:1486–92.

Creatsas G, Deligeoroglou E, Makrakis E, Kontoravdis A.

Papadimitriou L. Creation of a neovagina following Williams

vaginoplasty and Creatsas modification in 111 patients with

Mayer-Rokitansky-Kuster-Hauser syndrome. Fertil Steril

;76:1036–40.

Kim C, Campbell B, Ferrer F. Robotic sigmoid vaginoplasty:

a novel technique. Urology 2008;72:847–9.

El-Saman AM. Retropubic balloon vaginoplasty for

management of Mayer-Rokitansky-Kuster-Hauser syndrome.

Fertil Steril 2009; (Epub ahead of print).

Dua HS, Azuara-Blanca A. Amniotic membrane

transplantation. Br J Opthalmol 1999;83:748–52.


Refbacks

  • There are currently no refbacks.


Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]