Samina Zaman, Sarosh Majid, Mahvish Hussain, Omer Chughtai, Javed Mahboob, Sohail Chughtai


Background: Ovaries are common site of non-neoplastic and neoplastic lesions. They can present
from the neonatal period to post menopause. Most are functional in nature and resolve with minimal
treatment. Objective of the study was to determine the nature of various ovarian lesions and to ascertain
the frequency and distribution of the various non-neoplastic and neoplastic lesions. Methods: The
study was a retrospective review of all cases of ovarian cancer, benign ovarian neoplasm and functional
ovarian cysts received during Jan–Dec 2008 at Chughtai’s Lahore Laboratory. The clinical data of the
patients was obtained from their respective files. Results: A total of 498 different non-neoplastic and
neoplastic lesions were seen during one calendar year 2008. Non-neoplastic cysts were more common
(343, 68.87%) than neoplastic tumours (155, 31.12%). The commonest non-neoplastic cyst was luteal
cyst followed by follicular cyst. Among the neoplastic tumours 78.70% were benign and 21.29% were
malignant. Benign serous cysts were the commonest benign tumour followed by mature cystic teratoma
and mucinous cyst. Serous cystadenocarcinoma was the commonest malignant tumour followed closely
by endometrioid carcinoma and granulosa cell tumour. Krukenberg tumour, tumour metastatic to
ovaries and non-Hodgkins lymphoma was also diagnosed during this period. Malignant germ cell
tumours were seen in much younger age group followed by sex cord stromal tumours. Epithelial
tumours were seen in much older age group. Conclusion: The morphologic diversity of ovarian masses
poses many challenges. A specific diagnosis can usually be made by evaluating routinely stained slides
but sometimes immunohistochemistry is required in difficult cases. Gross features also provide useful
diagnostic clues.
Keywords: Ovarian functional cysts, ovary, ovarian neoplasm

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