Mohammad Shoaib Khan, Zahoor Ahmed, Shah Jehan, Fasseh -uz- Zaman, Salim Khan, Safeer Zaman, Farid Ullah Shah


Background: Antibiotics are used to eradicate the pre- and postoperative infections in surgical
procedures and in all others medical cases. However, inappropriate and indiscriminate use of
antimicrobial agents can potentially have a number of problems. The emergence of antimicrobial
resistant bacteria, an increased number of patients experiencing adverse drug events, and increased
drug-related cost have been documented. The objective of the study was to determine the trend of
use of antibiotics and hospitalisation of patients in various units of a tertiary care hospital, to
investigate practice variation of antimicrobial agents within the hospital, and to identify and
document any opportunity for its improvement. Methods: A questionnaire containing relevant
information about the study was prepared. Patients’ age, sex, diagnosis, duration of hospital stay and
type of antibiotic used were recorded and analysed, with particular reference to antibiotic group and
disease pattern, in 3 different treatment areas of Hayatabad Medical Complex (HMC), Peshawar,
Pakistan, from July 2006 to June 2007. Results: During the period under report, a total of 519
patients were studied for their disease and the type of antibiotics used. The leading type of antibiotics
reported were 3rd generation antibiotic used on 147 (28.33%) patients in the 3 units collectively, 1st
generation 127 (24.47%), and penicillin 99 (19.08%), while macrolides were the least used.
Conclusion: The available resources are needed to be effectively utilised, to minimise the hospital
stay due to rational use of antibiotics, and to minimise burden of antibiotics on poor patients.
Keywords: Antibiotic usage, Tertiary care hospital, Peshawar, Pakistan

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